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The Good Kind of Brainwashing Scientists are exploring why the glymphatic system, which helps clear waste from the brain, declines with age and whether slowing that decline can improve aging. Share This December 10, 2020 About seven years ago, Maiken Nedergaard, a neuroscientist at New York State’s University of Rochester Medical Center (URMC), and colleagues noticed a striking change in the mice they were studying. The researchers were using a microscope to spy on the animals’ brains and track the movement of the cerebrospinal fluid (CSF) that surrounds and cushions that organ. When the mice were awake, only a trickle of fluid entered the brain. But whenever the animals were unconscious either asleep or anesthetized the floodgates opened. “We saw that CSF was recycled back into the brain in anesthetized and naturally sleeping mice, but this didn’t happen in awake mice,” says Nedergaard, an investigator with the Simons Collaboration on Plasticity and the Aging Br

United statesVanderbilt universityMaiken nedergaardJonathan kipnisDan xueHumberto mestreLaura lewisDaniel claassenJeff iliffIan harrisonUniversity college londonVanderbilt university medical centerBoston universityWashington university school of medicineVa puget sound health care systemUniversity of washington