Working to develop new treatments for osteoarthritis, researchers at Washington University School of Medicine in St. Louis have genetically engineered cartilage to deliver an anti-inflammatory drug in response to activity similar to the bending of a knee or other motions that put stress on joints.
Engineered Cartilage Releases Anti-inflammatory Drug to Protect against Joint Stress
January 28, 2021
Working to develop new treatments for osteoarthritis, researchers at Washington University School of Medicine in St. Louis have harnessed synthetic biology and tissue engineering technologies to generate genetically engineered cartilage that can deliver an anti-inflammatory drug in response to activity similar to the bending of a knee or other movements that put stress on joints.
“Drugs such as ibuprofen and naproxen that ease joint pain and lower systemic inflammation are the main treatments for osteoarthritis pain, but there are no therapies that actually prevent damage in the joints of patients with this debilitating form of arthritis,” said senior investigator Farshid Guilak, PhD, the Mildred B. Simon professor of orthopedic surgery. “We’ve developed a new field of research called mechanogenetics, where we can engineer cartilage cells to respond to the mechanical loadi
January 15, 2021 SHARE Researchers at Washington University School of Medicine have received a $791,317 grant from the National Institutes of Health (NIH) to study factors that keep pregnant women from getting tested for COVID-19, to evaluate whether it is important to test women regularly during their pregnancies, and to determine whether pregnant women with COVID-19 need more specialized prenatal care. (Photo: Getty Images)
Pregnant women with COVID-19 face an increased risk of complications from the illness, including preterm birth, delivery by cesarean section, and, compared with other women of the same age, higher likelihood of death or admission to an intensive care unit.
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IMAGE: Lead author of the study, Dr. Kelsey Collins is a postdoctoral fellow in Guilak s laboratory. view more
Credit: Shriners Hospitals for Children
(St. Louis) - A new study by investigators at the Shriners Hospital for Children St. Louis suggests the damaging effects of obesity are not due to body weight but rather come from something much smaller - biochemical signals released by fat cells.
The study focuses on the link between overweight or obesity and the development of osteoarthritis, a painful disease of the joints. The investigation was led by Dr. Farshid Guilak, director of the St. Louis Shriners Hospital Research Center.
St. Louis (PRWEB) January 05, 2021 A new study by investigators at Shriners Hospital for Children® St. Louis suggests the damaging effects of obesity are