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GSRGT 2020: Management of Chemotherapy-Resistant Germ Cell Tumors in 2020
(Urotoday.com) To kick-off a series of lectures discussing testicular cancer at the inaugural meeting of the Global Society of Rare Genitourinary Tumors (GSRGT) 2020 virtual summit, Dr. Andrea Necchi provided the keynote lecture discussing the management of chemotherapy-resistant germ cell tumors. Dr. Necchi started by highlighting the global incidence and mortality of germ-cell tumors:
As follows is an overview of first- and subsequent salvage treatment options:
10-20% of patients will progress/relapse after first-line therapy
A proportion varying from 25% to 60-70% of patients with will be cured by second-line treatments
There are very few randomized trials to guide treatment decisions
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IMAGE: Schematic illustration of how brain imaging resp. cerebrospinal fluid measures the accumulation of amyloid protein. view more
Credit: The research team.
The two used methods for detecting amyloid pathology in Alzheimer s disease do not give unambiguous results, with the risk of incorrect or delayed care interventions. Now, researchers at Karolinska Institutet in Sweden have found genetic explanations for the differences. The study is published in
Molecular Psychiatry and may be important for more individual diagnostics and the development of future drugs.
Alzheimer s disease is the most common dementia disease and leads to gradual memory loss and premature death. Approximately 120,000 people in Sweden have Alzheimer s and there are approximately 50 million people worldwide. According to Hjärnfonden, the number will increase by 70 percent in 50 years, partly because we are living longer and longer.
Date Time
Genetic differences important for Alzheimer’s diagnosis
The two used methods for detecting amyloid pathology in Alzheimer’s disease do not give unambiguous results, with the risk of incorrect or delayed care interventions. Now, researchers at Karolinska Institutet have found genetic explanations for the differences. The study is published in Molecular Psychiatry and may be important for more individual diagnostics and the development of future drugs.
Arianna Sala, currently a post-doctoral fellow at the University of Liège, Belgium and Technical University of Munich, and first author. Photo: Francesco Ciurlo.
Alzheimer’s disease is the most common dementia disease and leads to gradual memory loss and premature death. Approximately 120,000 people in Sweden have Alzheimer’s and there are approximately 50 million people worldwide. According to Hjärnfonden, the number will increase by 70 percent in 50 years, partly because we are living longer and longer.
The two clinically used methods for detecting amyloid pathology in Alzheimer's disease do not give unambiguous results, with the risk of incorrect or delayed care interventions.