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COVID-19 vaccine offers lesser, delayed protection against infection in people with cirrhosis A study shows for the first time that people with cirrhosis who receive mRNA COVID-19 vaccination gain important protection against more serious outcomes like hospitalization and death. At the same time, however, the vaccines offer less protection against SARS-CoV-2 infection and take longer to take effect in this population. Before this research, published July 13 in JAMA Internal Medicine, how much protection the vaccines offered people with cirrhosis was unknown. Clinical trials of the vaccines excluded most people with cirrhosis and other chronic conditions. So lead author Binu V. John, M.D., M.P.H., and his colleagues sought their own answers, speculating that cirrhosis immune dysregulation could alter vaccine response.

United statesUniversity of pennsylvaniaBinuv johnAndrew scheinbergEmily hendersonYale universityVeterans health administrationBrucew carter va medical centerVirginia commonwealth universityUniversity of miami miller school medicineMiami miller schoolVeterans healthHospitalization among patients with cirrhosisWest havenஒன்றுபட்டது மாநிலங்களில்பல்கலைக்கழகம் ஆஃப் பென்சில்வேனியா