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Mouse model closely reproduces human fatty liver disease
A team at Baylor College of Medicine and other institutions has developed a novel mouse model that reproduces many key features of human non-alcoholic fatty liver disease (NAFLD), a little-understood condition that significantly increases the risk of inflammation, fibrosis and liver cancer and ultimately requires liver transplant. With this model, researchers have an opportunity to advance the understanding and treatment of this serious condition for which there is no effective therapy. The study appeared in JHEP Reports.
“NAFLD has been difficult to study since we had no good animal model,” said corresponding author Dr. Karl-Dimiter Bissig, who was at Baylor during the development of this project and is now at Duke University.
Michael Enriquez Appointed President, HSS Florida
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Michael Enriquez Appointed President, HSS Florida
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As the California coronavirus variant continues to spread across the Golden State and beyond, new research suggests that several vaccines should continue to provide an effective defense against it.
The findings, published Wednesday in the New England Journal of Medicine, offer good reason for Californians to keep rolling up their sleeves as the vaccination campaign picks up steam across the state.
“We’re not expecting this variant to be a problem for the vaccines so that’s really good news,” said study leader David Montefiori, a virologist at Duke University.
The California variant is actually a pair of closely related fellow travelers known as B.1.427 and B.1.429. Scientists say they most likely emerged in the state in May, then surged to become the dominant strain amid the deadly holiday surge.