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Secret genetic switch in zebrafish key to heart regeneration
Scientists have discovered a critical new gene in zebrafish that helps them repair damaged heart muscle.
Researchers at the Victor Chang Cardiac Research Institute (VCCRI) and UNSW Sydney have identified a genetic switch in zebrafish that turns on cells, allowing them to divide and multiply after a heart attack and resulting in the complete regeneration and healing of damaged heart muscle in these fish.
It’s already known that zebrafish can heal their own hearts, but how they performed this incredible feat remained unknown until now. In research published this month in Science, the team drilled down into a critical gene known as Klf1 that previously had only been identified in red blood cells. For the first time they discovered it played a vital role in healing damaged hearts.
After injury, zebra fish can regrow heart tissue. A new study investigates the mechanisms and asks whether we could use this knowledge to treat humans.
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âRockstar bankerâ Grounds to join rapidly rising Barrenjoey Capital
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By Ingrid Pyne
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The investment banking worldâs worst kept secret will be confirmed early next week when former UBS boss Matthew Grounds formally joins the rapidly growing startup Barrenjoey Capital Partners as co-executive chairman.
Mr Grounds - dubbed the ârockstar bankerâ for his dealings with billionaires James Packer, Kerry Stokes and Frank Lowy - will share the top executive job with Guy Fowler, his former right-hand man at UBS, according to sources familiar with the appointment. The sources also said that he will join Barrenjoeyâs board after it is reconstituted which is expected imminently.
Victor Chang Cardiac Research Institute
Scientists at the Victor Chang Cardiac Research Institute have discovered a critical new gene that it is hoped could help human hearts repair damaged heart muscle after a heart attack.
Researchers have identified a genetic switch in zebrafish that turns on cells allowing them to divide and multiply after a heart attack, resulting in the complete regeneration and healing of damaged heart muscle in these fish.
It’s already known that zebrafish can heal their own hearts, but how they performed this incredible feat remained unknown, until now. In research recently published in the prestigious journal, Science, the team at the Institute drilled down into a critical gene known as Klf1 that previously had only been identified in red blood cells. For the first time they discovered it plays a vital role in healing damaged hearts.