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by Tracey Peake April 14, 2021 . RALEIGH – Bacteria – such as E. coli – harness biosynthesis to create molecules that are difficult to make artificially. “We already use bacteria to make a number of drugs for us,” says Edward Kalkreuter, former graduate student at NC State and lead author of a paper describing the research. “But we also want to make alterations to these compounds; for example, there’s a lot of drug resistance to erythromycin. Being able to make molecules with similar activity but improved efficacy against resistance is the general goal.” Picture an automobile assembly line: each stop along the line features a robot that chooses a particular piece of the car and adds it to the whole. Now substitute erythromycin for the car, and an acyltransferase (AT) – an enzyme – as the robot at the stations along the assembly line. Each AT “robot” will select a chemical block, or extender unit, to add to the molecule. At each station the AT robot has

United statesKyle binghamAaron keelerGavin williamsJennifer schmidtAndrew lowellEdward kalkreuterDavid shermanScripps research instituteNature communicationsNational institutes of healthCorporation distinguished scholarUniversity of michiganDistinguished scholarNational institutesScripps research