CRISPRa identifies potassium channels as neuronal entry factors and druggable targets for SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes various symptoms that go beyond respiratory problems. Neurological, cardiac, and other issues can emerge during infection and after recovery in long COVID, suggesting SARS-CoV-2 invades several organs. However, how SARS-CoV-2 invades the brain whether directly or indirectly remains under investigation.
New research led by Le Cong of Stanford University School of Medicine in California indicates that the KCNA6 potassium channel may help with viral entry and promote infection. In addition, KCNA6 is highly expressed in OLIG2+ neuronal cells, which has been shown to be suspectable to SARS-CoV-2 in the olfactory neuroepithelium. This area appears to contribute to loss of smell commonly observed during infection.
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