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HIV Infection: Fresh Insights

HIV Infection: Fresh Insights For the first time EMBL Heidelberg and at the Zentrum für Infektiologie at Heidelberg University Hospital scientists have succeeded in imaging HIV during transport into the nucleus of an infected cell. The electron tomographic images show the protein envelope of the virus passing through one of the nuclear pores - the openings in the membrane around the nucleus that allow molecules in and out. This clarifies an important mechanism by which the virus s genetic material is integrated into the genome of the infected cell. ‘The scientists found that the HIV virus passes through the nuclear pore intact, only breaking apart inside the nucleus, where it releases its genetic information.’

Infektiologie at heidelberg university hospitalHeidelberg university hospitalHiv virusHiv infectionஹைடெல்பெர்க் பல்கலைக்கழகம் மருத்துவமனைஎசைவீ வைரஸ்எசைவீ தொற்று

Researchers use high-resolution imaging to observe HIV infection process in the cell nucleus

Researchers use high-resolution imaging to observe HIV infection process in the cell nucleus Scientists at EMBL Heidelberg and at the Zentrum für Infektiologie at Heidelberg University Hospital have succeeded for the first time in imaging HIV during transport into the nucleus of an infected cell. The electron tomographic images show the protein envelope of the virus passing through one of the nuclear pores - the openings in the membrane around the nucleus that allow molecules in and out. The scientists found that the virus passes through the nuclear pore intact, only breaking apart inside the nucleus, where it releases its genetic information. This clarifies an important mechanism by which the virus s genetic material is integrated into the genome of the infected cell.

Emily hendersonInfektiologie at heidelberg university hospitalHeidelberg university hospitalMedical directorCell nucleusElectron microscopyGenetic informationஎமிலி ஹென்டர்சன்ஹைடெல்பெர்க் பல்கலைக்கழகம் மருத்துவமனைமருத்துவ இயக்குனர்செல் கருஎதிர் மின்னணுஎதிர் மின்னணு நுண்ணோக்கிஜெநெடிக் தகவல்

A new piece of the HIV infection puzzle explored

E-Mail Scientists at EMBL Heidelberg and at the Zentrum für Infektiologie at Heidelberg University Hospital have succeeded for the first time in imaging HIV during transport into the nucleus of an infected cell. The electron tomographic images show the protein envelope of the virus passing through one of the nuclear pores - the openings in the membrane around the nucleus that allow molecules in and out. The scientists found that the virus passes through the nuclear pore intact, only breaking apart inside the nucleus, where it releases its genetic information. This clarifies an important mechanism by which the virus s genetic material is integrated into the genome of the infected cell.

Infektiologie at heidelberg university hospitalHeidelberg university hospitalMedical directorCell biologyMolecular biologyMedicine healthAids hivInfectious emerging diseasesஹைடெல்பெர்க் பல்கலைக்கழகம் மருத்துவமனைமருத்துவ இயக்குனர்செல் உயிரியல்மூலக்கூறு உயிரியல்மருந்து ஆரோக்கியம்எய்ட்ஸ் எசைவீதொற்று வளர்ந்து வருகிறது நோய்கள்

A new piece of HIV infection puzzle explored

A new piece of HIV infection puzzle explored
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Martin beckElectron microscopy core facility at heidelberg universityHeidelberg university hospitalInfektiologie at heidelberg university hospitalElectron microscopy service platformMedical directorElectron microscopy core facilityHeidelberg universityCryo electron microscopy service platformScientific memberMax planck instituteமார்டின் பெக்ஹைடெல்பெர்க் பல்கலைக்கழகம் மருத்துவமனைஎதிர் மின்னணு நுண்ணோக்கி சேவை நடைமேடைமருத்துவ இயக்குனர்எதிர் மின்னணு நுண்ணோக்கி கோர் வசதி

Finding coronavirus s helper proteins

EMBL scientists identify human proteins hijacked by coronavirus, offering potential drug targets EMBL scientists used a biophysical method called thermal proteome profiling (TPP) to gain a comprehensive overview of which human proteins are functionally altered at different times during SARS-CoV-2 infection. Credit: Holly Joynes/EMBL A group of scientists led by EMBL’s Mikhail Savitski, Nassos Typas, and Pedro Beltrao, and collaborator Steeve Boulant at Heidelberg University Hospital, have analysed how the novel coronavirus affects proteins in human cells. They identified several human proteins as potential drug targets to prevent viral replication. The researchers used a biophysical method called thermal proteome profiling (TPP) to gain a comprehensive overview of which human proteins are functionally altered during SARS-CoV-2 infection. TPP monitors protein amounts and denaturation temperatures – the points at which proteins heat up so much that they lose their 3D structure

Baden wubergHolly joynesMikhail savitskiNassos typasPedro beltraoTechnical university of munichEuropean bioinformatics instituteSteeve boulant at heidelberg university hospitalHeidelberg university hospitalGerman cancer research centerSteeve boulantGenome biology unitCore facilityBioinformatics instituteTechnical universityUniversity of munich