with the pain and swelling of my moderate to severe rheumatoid arthritis... ordinary objects often seemed... intimidating. doing something simple... meant enduring a lot of pain. if ra is changing your view of everyday things orencia may help. orencia works differently by targeting a source of ra early in the inflammation process. for many, orencia provides long-term relief of ra symptoms. it's helped new ra patients and those not helped enough by other treatments. do not take orencia with another biologic medicine for ra due to an increased risk of serious infection. serious side effects can occur including fatal infections. cases of lymphoma and lung cancer have been reported. tell your doctor if you're prone to or have any infection like an open sore, the flu, or a history of copd, a chronic lung disease.