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Nitrosamines are carcinogenic, even at trace levels. As a result, the FDA has issued guidance regarding monitoring nitrosamine impurities in drugs for human consumption [1].
Synthetic replicas of endogenous steroids are both chemically and pharmacologically indistinguishable from their natural counterparts. By examining isotopes within these steroids, distinct isotope fingerprints emerge in urinary samples, creating a reliable discrimination framework. Explore the concept of Isotope Fingerprints and their application in doping control investigations. Discover how these fingerprints play a crucial role in distinguishing between naturally produced (endogenous) and ext
Stable isotope labelling is a powerful technique which allows tracking down drug metabolism. This application brief reports how isotope fingerprints have been effectively investigated to detect labeled metabolites of drug of abuse by using gas chromatography isotope ratio mass spectrometry (IRMS).
Breath samples, specifically volatile organic compounds (VOCs), have been explored for decades to identify health and disease changes. Advances in genomics and metabolomics, along with high-throughput analysis, have expanded this field. Breath testing, as a non-invasive tool, facilitates early disease detection and personalized treatment through precision medicine. The Breath Biopsy™ method, using Orbitrap™ technology, is a breakthrough for pain-free and reliable testing, providing insights into
Analyzing trace elements in biological samples is crucial for clinical research, offering insights into cellular functions. Essential elements like zinc, copper, selenium, and others play vital roles in biochemical reactions. Increased exposure to toxic heavy metals poses health risks. This study reports an analytical method for quantifying 28 trace elements in human plasma and serum, utilizing the ClinMass Complete Kit and Thermo Scientific™ iCAP™ TQ ICP-MS.