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UNSW researchers find novel way to attack the 'fortress' surrounding pancreatic tumors


UNSW researchers find novel way to attack the 'fortress' surrounding pancreatic tumors
May 17 2021
Tackling the scar tissue that shields pancreatic tumors from effective drug access is a promising advance in a notoriously hard-to-treat cancer.
Dr George Sharbeen and Associate Professor Phoebe Phillips in their lab. Photo: Richard Freeman / UNSW
UNSW medical researchers have found a way to starve pancreatic cancer cells and ‘disable’ the cells that block treatment from working effectively. Their findings in mice and human lab models – which have been 10 years in the making and are about to be put to the test in a human clinical trial – are published today in

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Scientists show how to attack 'fortress' surrounding pancreatic cancer tumours

Tackling the scar tissue that shields pancreatic tumours from effective drug access is a promising advance in a notoriously hard-to-treat cancer. ...

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Scientists show how to attack the 'fortress' surrounding pancreatic cancer tumours – India Education | Latest Education News India | Global Educational News


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UNSW medical researchers have found a way to starve pancreatic cancer cells and ‘disable’ the cells that block treatment from working effectively. Their findings in mice and human lab models – which have been 10 years in the making and are about to be put to the test in a human clinical trial – are published today in 
Cancer Research, a journal of the American Association for Cancer Research.
“Pancreatic cancer has seen minimal improvement in survival for the last four decades – and without immediate action, it is predicted to be the world’s second biggest cancer killer by 2025,” says senior author Associate Professor Phoebe Phillips from UNSW Medicine & Health.

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Scientists show how to attack the 'fortress' surrounding pancreatic cancer tumors


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Credit: UNSW Sydney
UNSW medical researchers have found a way to starve pancreatic cancer cells and 'disable' the cells that block treatment from working effectively. Their findings in mice and human lab models - which have been 10 years in the making and are about to be put to the test in a human clinical trial - are published today in
Cancer Research, a journal of the American Association for Cancer Research.
"Pancreatic cancer has seen minimal improvement in survival for the last four decades - and without immediate action, it is predicted to be the world's second biggest cancer killer by 2025," says senior author Associate Professor Phoebe Phillips from UNSW Medicine & Health.

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New hope for Aussies living with pancreatic cancer


The team found a way to metabolically rewire tumours by targeting a protein called SLC7A11.
"We found that switching off SLC7A11 in mice with pancreatic tumours directly killed pancreatic cancer cells, reduced the spread of tumour cells throughout their body and decreased the scar tissue fortress," said Dr George Sharbeen, a postdoc researcher who led the experimental work.
The promising results were mirrored in experiments using patient tumour samples.
"Our latest advance means today I am the most optimistic and hopeful I have been in my career," said Associate Professor Phillips.
The anti-arthritis drug called sulfasalazine also blocks this protein and will now be repurposed for the Phase II clinical trial.

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Pancreatic cancer clinical trial program to target genome and scar tissue

UNSW Sydney and the Garvan Institute of Medical Research researchers will lead the program, thanks to a $3.75 million grant from the Cancer Institute...

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