NIH scientists discover new B cell that tempers autoimmunity
Findings in mice point to potential therapies for blinding eye disease uveitis and multiple sclerosis.
Source: nih.gov
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NEI researchers identify unique population of B cells that tamps down the immune system
Researchers at the National Eye Institute (NEI) have identified, isolated, and characterized a unique population of B cells that tamps down the immune system, reducing chronic inflammation.
Source: news-medical.net
Characterization of B-cell receptor repertoires in COVID-19 patients
In a new study published in the journal Human Immunology, scientists sought to better understand how B-cell immune repertoire changes over time during SARS-CoV-2 infection by comprehensively characterizing the dynamics of immunoglobin heavy chain (IGH) repertoire in COVID-19 patients.
Source: news-medical.net
Importance of cross-neutralizing antibodies against SARS-CoV-2 variants
A new study published in the journal mBio investigates different antibodies from convalescent donors that bind three separate domains of the SARS-CoV-2 spike. The results of this study suggest that the individuals exposed to the SARS-CoV-2 from the first wave have neutralizing antibodies against current variants.
Source: news-medical.net
GABA secreted by B-cells blunts the body's cytotoxic T-cell-based response to tumors
A group of scientists led by researchers from the RIKEN Center for Integrative Medical Sciences have discovered that B-cells, a type of immune cell, secrete the neurotransmitter GABA, and also found that the GABA secreted by the B-cells promoted the emergence of anti-inflammatory macrophages, blunting the body's cytotoxic T-cell-based response to tumors.
Source: news-medical.net