Meet the Smurfs: A bone metabolism family
Smurf2-deficient mice. In the Smurf2-deficient mice, ectopic bone induced by bone morphogenetic protein (BMP) was large and composed of abundant trabecular bone.... view more Credit: Bone Research (Springer Nature) ISSN 2095-6231 (online) Osaka, Japan - Bone morphogenetic protein (BMP) has a strong osteogenic (bone forming) ability. BMP has already been clinically applied to spinal fusion and non-union fractures. However, dose-dependent side effects related to BMP use, such as inflammatory reactions at the administration site, prevent widespread use. For safe use, it was necessary...
Source: eurekalert.org