Page 41 - Cell Reports News Today : Breaking News, Live Updates & Top Stories | Vimarsana

Researchers find α-synuclein spreads via the brain lymphatic system before aggregation in Parkinson's disease.

Parkinson’s disease is characterized by the presence of fibrils of α-synuclein. It has been shown that α-synuclein fibrils can be transmitted from neuron to neuron. However, whether α-synuclein spreading occurs before its aggregation remains unclear. Researchers from Tokyo Medical and Dental University (TMDU) showed that monomeric α-synuclein can propagate through the brain lymphatic system before it aggregates. This study might contribute to the development of new strategies to limit the progression of Parkinson’s disease.

Researchers with the Johns Hopkins Kimmel Cancer Center, the Johns Hopkins University School of Medicine and four other institutions have developed a molecular test to identify the presence of brain tumors by measuring abnormal genetic material shed by tumors and circulating in cerebrospinal fluid (CSF).

Although antiretroviral therapies are the standard of care treatment for those with HIV, the drugs cannot target latent infections; however, venetoclax, a blood cancer treatment, shows promise.

Researchers with the Johns Hopkins Kimmel Cancer Center, the Johns Hopkins University School of Medicine and four other institutions have developed a molecular test to identify the presence of brain tumors by measuring abnormal genetic material shed by tumors and circulating in cerebrospinal fluid (CSF). A description of the work was published Aug. 15 in the journal Cell Reports Medicine.