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Novel Co-Admin of CAR T Cells Achieves 99% Remission in Leukemia

In the largest study to date of CAR T-cell therapy for relapsed and refractory childhood B-cell acute lymphoblastic leukemia, a novel approach led to undetectable disease in nearly all patients.

China , Pennsylvania , United-states , Shanghai , Tennessee , Philadelphia , Lebanon , Lebanese , American , National-natural-science-foundation-of-china , American-society-of-clinical-oncology

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Scientists atSt. JudeChildren’s Research Hospital are working with colleagues in China to develop better therapy for childhood acute lymphoblastic leukemia (ALL). Results from a large phase 3 noninferiority clinical trial definitively showed that vincristine and dexamethasone pulses can be eliminated in patients with low-risk disease. The findings were published today in
The
Lancet Oncology.
Adding the chemotherapy vincristine plus a steroid (originally prednisone, and later dexamethasone) as pulse therapy for childhood ALL has been part of standard care since the 1970s. This is despite their being associated with neuropsychological side effects, neuropathy and other late effects. However, to date studies about the need for prolonged treatment with pulse therapy have been inconclusive.

Tongji , Sichuan , China , Huazhong , Hubei , Shanghai , Hong-kong , Nanjing , Jiangsu , Hua-jiang , Guangxi , Guangzhou

International collaboration helps refine treatment for childhood leukemia

International collaboration helps refine treatment for childhood leukemia
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Tongji , Sichuan , China , Huazhong , Hubei , Shanghai , Hong-kong , Nanjing , Jiangsu , Hua-jiang , Guangxi , Guangzhou

Delaying first spinal tap may lower risk of pediatric leukemia relapse

Corresponding author Ching-Hon Pui, M.D., chair of the St. Jude Department of Oncology, contributed to international research that helps predict and...

China , Li-zhang , Zhejiang , Cheng , Shaanxi , Chongqing , Shanghai , Hong-kong , Jingyan-tang , Chi-kong-li , Junj-yang , Jiaoyang-cai