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Investigating a role for complement in gene therapy

Immunology expert discusses the complement system, immunogenicity challenges in AAV-mediated gene therapy, and more ....

Klaudia Kuranda , Anna Majowicz , Technology Department At Spark Therapeutics , Technology Department , Editorial Article , Spark Therapeutics , Preclinical Immunology Lead , Svar Life Science , Functional Complement Assays , Complement System , Complement System Alternative Pathway , Complement System Classical , The Importance Of Investigating Complement System In Gene Therapy Selectscience Aav , Av Gene Therapy , Omplement Activiation , Av Capsid Specifict Cells , Aav Vectors ,

Complement system could provide cancer prognostic biomarkers

Context-dependent role of complement in cancer could provide novel prognostic biomarkers to inform treatment decisions ....

France General , Fridman Wh Context Dependent , Lubka Roumenina , Cordeliers Research Center , Cancer Team , French National Institute Of Health , Editorial Article , Senior Scientist , French National Institute , Medical Research , Deputy Director , Cordeliers Research , Complement Biomarker Assays , Functional Complement Assays , Svar Life Science , Svar Life , Rev Cancer , Prognostic Biomarkers , Adrenal Cancer , Noncanonical Functions , The Complement System Provides Promise Of Novel Prognostic Biomarkers For Cancer Selectscience , Omplement Biomarker Assay , Complement System , Prognostic Biomarkers ,

Complement system could provide cancer prognostic biomarkers

Context-dependent role of complement in cancer could provide novel prognostic biomarkers to inform treatment decisions ....

France General , Fridman Wh Context Dependent , Lubka Roumenina , Cancer Team , Cordeliers Research Center , French National Institute Of Health , Editorial Article , Senior Scientist , French National Institute , Medical Research , Deputy Director , Cordeliers Research , Complement Biomarker Assays , Functional Complement Assays , Svar Life Science , Svar Life , Rev Cancer , Prognostic Biomarkers , Adrenal Cancer , Noncanonical Functions , The Complement System Provides Promise Of Novel Prognostic Biomarkers For Cancer Selectscience , Omplement Biomarker Assay , Complement System , Prognostic Biomarkers ,

Complement dysregulation is key feature of severe COVID-19

Research led by investigators at Ghent University in Belgium showed dysregulation of the complement part of the immune system, regulated by the pro-inflammatory protein interleukin (IL)-6, is a key driver of severe COVID-19 and a good target for drugs to treat the effects of the disease. ....

Ghent University , Science Translational Medicine , Covid 19 , Il 6 , Complement System , Sars Cov 2 ,

"The Emerging Roles of Extracellular Chaperones in Complement Regulatio" by Nicholas J. Geraghty, Sandeep Satapathy et al.

The immune system is essential to protect organisms from internal and external threats. The rapidly acting, non-specific innate immune system includes complement, which initiates an inflammatory cascade and can form pores in the membranes of target cells to induce cell lysis. Regulation of protein homeostasis (proteostasis) is essential for normal cellular and organismal function, and has been implicated in processes controlling immunity and infection. Chaperones are key players in maintaining proteostasis in both the intra- and extracellular environments. Whilst intracellular proteostasis is well-characterised, the role of constitutively secreted extracellular chaperones (ECs) is less well understood. ECs may interact with invading pathogens, and elements of the subsequent immune response, including the complement pathway. Both ECs and complement can influence the progression of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease ....

Complement System , Xtracellular Chaperone , Protein Aggregation , Protein Folding ,