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Monitoring Cytokine Storms in Real Time

Monitoring Cytokine Storms in Real Time
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Monitoring Cytokine Storms in Real Time

This Biotech Brief discusses the significance of cytokine storms and methods and justifications for monitoring inflammatory mediators to prevent poor clinical outcomes, choose appropriate interventions, and reduce mortality. Pathogens, autoimmune and malignant diseases, genetic disorders, and some therapeutic interventions can lead to life-threatening systemic inflammatory syndromes—cytokine release syndrome (CRS) or cytokine storm (CS)—that are characterized by is a massive release of cytokines due to excessive activation of immune cells.

Sacha-gnajtic , Steve-crouse , Miriam-merad , Olegs-glotov , Lab-chip , Mount-sinai-human-immune-monitoring-center , A-university-of-michigan , Mount-sinai , Human-immune-monitoring-center , Predictive-risk-factors , Cytokine-storms , Inflammatory-profile-correlates

A comparison of SARS-CoV-2 and influenza cytokine storms

In a recent study published in the Journal of Interferon & Cytokine Research, researchers compared the cytokine storms of pandemic influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

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Frontiers | An Update on Protective Effectiveness of Immune Responses After Recovery From COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibits variable immunity responses among hosts based on symptom severity. Whether immunity in recovered individuals is effective for avoiding reinfection is poorly understood. Determination of immune memory status against SARS-CoV-2 helps identify reinfection risk and vaccine efficacy. Hence, after recovery from COVID-19, evaluation of protective effectiveness and durable immunity of prior disease could be significant. Recent reports described the dynamics of SARS-CoV-2 -specific humoral and cellular responses for more than six months in convalescent SARS-CoV-2 individuals. Given the current evidence, NK cell subpopulations, especially the memory-like NK cell subset, indicate a significant role in determining COVID-19 severity. Still, the information on the long-term NK cell immunity conferred by SARS-CoV-2 infection is scant. The evidence from vaccine clinical trials and observational studies indicates that hybrid natural/vaccine immunity to SARS-CoV-2 seems to be notably potent protection. We suggested the combination of plasma therapy from recovered donors and vaccination could be effective. This focused review aims to update the current information regarding immune correlates of COVID-19 recovery to understand better the probability of reinfection in COVID-19 infected cases that may serve as guides for ongoing vaccine strategy improvement.

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Alex Witt Reports-20211219-18:11:00

higher. and their risk of death is clearly higher. and a lot of this comes from what you've heard in the news called the cytokine storm, which is, those are molecules that help cells communicate, but they enhance inflammation and pregnant women are much more prone to be the victims of cytokine storms and sepsis in particular. and this can necessitate early delivery. it probably leads to two big complications, preeclampsia, which is a hypertensive disorder, specifically of pregnancy, and to premature labor. and i can't emphasize enough the importance of pregnant women getting vaccinated, vaccination does not lead to an increase in miscarriage. it does not degrees fertility. all of these are myths and lies that are on the internet. i can't emphasize enough, get

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People with Down syndrome prone to Covid-19 due to genetic susceptibility

People with Down syndrome prone to Covid-19 due to genetic susceptibility
February 09, 2021
Earlier studies have shown a tenfold mortality risk for people with Down syndrome if they contract coronavirus.
A new study aims to understand the genetic factors present in people with Down syndrome, making them susceptible to the coronavirus.
Earlier studies have shown a tenfold mortality risk for people with Down syndrome if they contract coronavirus.
Now, the new study, published in the journal Scientific Reports, noted that TMPRSS2, a gene that codes for an enzyme critical for aiding the entry of SARS-CoV-2 in human cells, had 60 per cent higher levels of expression in Down syndrome.

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