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Pain has been long recognized as one of evolution's most reliable tools to detect the presence of harm and signal that something is wrong -; an alert system that tells us to pause and pay attention to our bodies.
Pain neurons engage in direct cross-talk with goblet cells, or mucus-containing cells within the gut. During states of inflammation, pain cells stimulate goblet cells to release more mucus. Findings suggest the nervous system plays a key role in gut barrier maintenance and triggers protective mechanisms during periods of inflammation.