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Timing plant evolution with a fast-ticking epigenetic clock

Timing plant evolution with a fast-ticking epigenetic clock
sciencedaily.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencedaily.com Daily Mail and Mail on Sunday newspapers.

Munich , Bayern , Germany , United-states , American , Thorsten-reusch , Larsg-ljungdahl , Robert-schmitz , Nan-yao , Frank-johannes , Zhilin-zhang , University-of-georgia

Timing plant evolution with a fast-ticking epigenetic clock

Timing plant evolution with a fast-ticking epigenetic clock
phys.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from phys.org Daily Mail and Mail on Sunday newspapers.

United-states , Munich , Bayern , Germany , American , Frank-johannes , Larsg-ljungdahl , Robert-schmitz , Nan-yao , Zhilin-zhang , Thorsten-reusch , Franklin-college-of-arts

2017 Borlaug Dialogue Speakers - The World Food Prize - Improving the Quality, Quantity and Availability of Food in the World

2017 Borlaug Dialogue Speakers - The World Food Prize - Improving the Quality, Quantity and Availability of Food in the World
worldfoodprize.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from worldfoodprize.org Daily Mail and Mail on Sunday newspapers.

El-hatico , Departamento-de-norte-santander , Colombia , United-states , Alexandria , Al-iskandariyah , Egypt , United-kingdom , Delaware , Entebbe , Wakiso , Uganda

Navrogen Enters into CRADA with The U.S. National Cancer Institute for the Clinical Development of NAV-001, an Anti-Mesothelin Antibody-Drug Conjugate

/PRNewswire/ -- Navrogen, Inc. announced today that it has entered into a Cooperative Research and Development Agreement (CRADA) with researchers at the U.S....

Philadelphia , Pennsylvania , United-states , Ira-pastan , Nicholas-nicolaides , Steven-kyriakos , Luigi-grasso , Raffit-hassan , Development-agreement , Us-national-cancer-institute , Navrogen-incorporated , Laboratory-of-molecular-biology

Navrogen Enters into CRADA with The U.S. National Cancer Institute for the Clinical Development of NAV-001, an Anti-Mesothelin Antibody-Drug Conjugate

PHILADELPHIA, Nov. 7, 2022 /PRNewswire/ -- Navrogen, Inc. announced today that it has entered into a Cooperative Research and Development Agreemen...

Philadelphia , Pennsylvania , United-states , Ira-pastan , Nicholas-nicolaides , Steven-kyriakos , Luigi-grasso , Raffit-hassan , Development-agreement , Us-national-cancer-institute , Navrogen-incorporated , Laboratory-of-molecular-biology

Predicting major complications in patients undergoing laparoscopic and open hysterectomy for benign indications

Background: Hysterectomy, the most common gynecological operation, requires surgeons to counsel women about their operative risks. We aimed to develop and validate multivariable logistic regression models to predict major complications of laparoscopic or abdominal hysterectomy for benign conditions.

Methods: We obtained routinely collected health administrative data from the English National Health Service (NHS) from 2011 to 2018. We defined major complications based on core outcomes for postoperative complications including ureteric, gastrointestinal and vascular injury, and wound complications. We specified 11 predictors a priori. We used internal–external cross-validation to evaluate discrimination and calibration across 7 NHS regions in the development cohort. We validated the final models using data from an additional NHS region.

Results: We found that major complications occurred in 4.4% (3037/68 599) of laparoscopic and 4.9% (6201/125 971) of abdominal hysterectomies. Our models showed consistent discrimination in the development cohort (laparoscopic, C-statistic 0.61, 95% confidence interval [CI] 0.60 to 0.62; abdominal, C-statistic 0.67, 95% CI 0.64 to 0.70) and similar or better discrimination in the validation cohort (laparoscopic, C-statistic 0.67, 95% CI 0.65 to 0.69; abdominal, C-statistic 0.67, 95% CI 0.65 to 0.69). Adhesions were most predictive of complications in both models (laparoscopic, odds ratio [OR] 1.92, 95% CI 1.73 to 2.13; abdominal, OR 2.46, 95% CI 2.27 to 2.66). Other factors predictive of complications included adenomyosis in the laparoscopic model, and Asian ethnicity and diabetes in the abdominal model. Protective factors included age and diagnoses of menstrual disorders or benign adnexal mass in both models and diagnosis of fibroids in the abdominal model.

Interpretation: Personalized risk estimates from these models, which showed moderate discrimination, can inform clinical decision-making for people with benign conditions who may require hysterectomy.

United-kingdom , Sweden , Granada , Andalucísp , Spain , Bangladesh , United-states , Denmark , China , Finland , Canada , West-midlands

Top research institute selects 19 new members

Academia Sinica has selected 19 new academicians, the institution announced yesterday at its 34th Academician Convocation, which was delayed two years due to the COVID-19 pandemic.
Incoming academician Chen Li-chyong (林麗瓊), one of four women selected, told reporters that her decision to return to Taiwan in 1994 had been greatly influenced by then-Academia Sinica president Lee Yuan-tseh (李遠哲).
Chen thanked her husband, Chen Kuei-hsien (陳貴賢), who is also an academician at the institution, for encouraging her to return to the country.
Chen Li-chyong said her return coincided with the beginning of a boom in the nation’s tech sector.
The success of Taiwan Semiconductor Manufacturing

Yiting , Zhejiang , China , National-chengchi-university , T-ai-pei , Taiwan , California , United-states , Taipei , Kyoto , Japan , Tang

《TAIPEI TIMES》Top research institute selects 19 new members - 焦點

By Jake Chung / Staff writer, with CNAAcademia Sinica has selected 19 new academicians, the institution announced yesterday at its 34th Academician Convocation, which was delayed two years due to the COVID-19 pandemic.

National-chengchi-university , T-ai-pei , Taiwan , University-of-southern-california , California , United-states , China , Taipei , Kyoto , Japan , Chung-shan , Guangdong

Probe Reveals Top People With the NIH Getting Big Bucks From Secret Royalty Checks

Recipients of secret royalty payments who hold key roles at the National Institutes for Health (NIH) have been ...

United-states , American , Jeffrey-scholm , Adam-andrzejewski , Francis-collins , Richard-youle , Anthony-fauci , Lawrence-tabak , Joe-biden , Steven-rosenberg , John-schiller , Ethan-shevach

FDA Advisory Panel Rejects Novel ALS Drug

A US Food and Drug Administration advisory committee is unconvinced by that a new drug for amyotrophic lateral sclerosis is effective.

Phoenix , Arizona , United-states , Jamie-timmons , Joshua-cohen , Caleb-alexander , Kenneth-fischbeck , Amylyx-pharmaceuticals , Amylyx-pharmaceuticals-inc , National-institutes-of-health , Central-nervous-system-drugs-advisory-committee , Johns-hopkins-bloomberg-school-of-public-health