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The phenomenon of regeneration was discovered over 200 years ago in the freshwater polyp Hydra. Until now, however, it was largely unclear how the orderly regeneration of lost tissues or organs is activated after injury.
Years of work by developmental biologists from Trinity College Dublin, working with colleagues at the University of Edinburgh's MRC Human Genetics Unit, has yielded a resource of unparalleled detail that will help researchers assess how key genes control the differentiation of tissues and organs of developing embryos.
In biology, getting rid of stuff can be just as important as making it. A buildup of cells, proteins, or other molecules that are no longer needed can cause problems, so living things have evolved several ways to clean house.
Certain childhood tumors have an extreme need for amino acids. Scientists at the Hopp Children's Cancer Center Heidelberg (KiTZ), the German Cancer Research Center (DKFZ), the University of Heidelberg, and HI-STEM gGmbH have now discovered the molecular mechanisms underlying this and how the cancer cells could be turned off.
Children with Dravet syndrome, a severe form of epilepsy that begins in infancy, experience seizures, usually for their entire life.