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What is endometriosis and how can it affect fertility?


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The term endometriosis comes from the word 'endometrium', which is the uterine lining developed by your body each month in preparation for egg implantation. If a woman does not conceive within a month, the body sheds the endometrium and one gets their periods. The endometrial tissue passes through the fallopian tube and into the abdomen.
The tissue sometimes can bind to the other organs in some women. When the hormones are released during the next menstrual cycle, it causes the extra tissue to develop and then shed, much like the tissue in the uterus.
The bleeding and tissue shedding has no means of leaving the body, causing inflammation of local tissue. The discomfort felt by patients with endometriosis is often caused by inflammation.

Myovant Sciences and Pfizer Announce First Participant Dosed in Phase 3 SERENE Study Evaluating Contraceptive Efficacy of Once-Daily


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Myovant Sciences and Pfizer Announce First Participant Dosed in Phase 3 SERENE Study Evaluating Contraceptive Efficacy of Once-Daily
SERENE is a Phase 3 single-arm, open-label study evaluating the contraceptive efficacy of investigational relugolix combination tablet in sexually active, healthy women ages 18-35 years
Contraceptive potential of relugolix combination tablet supported by prior Phase 1 study that demonstrated 100% ovulation inhibition
Data would support a potential indication of pregnancy prevention for women treated with relugolix combination tablet, if approved
BASEL, Switzerland and NEW YORK, April 12, 2021 (GLOBE NEWSWIRE) — Myovant Sciences (NYSE: MYOV) and Pfizer Inc. (NYSE: PFE) today announced that the first participant has been dosed in the Phase 3 SERENE study evaluating the contraceptive efficacy of relugolix combination tablet (relugolix 40 mg, estradiol 1.0 mg, and norethindrone acetate 0.5 mg) in healthy women ages 18-35 years who are at risk for pregnancy.

How the conversation around endometriosis is changing

Where are we at with Endometriosis? What do we still not know?

Irish songwriter Ruth Anne opens up on her debilitating battle with endometriosis


Irish songwriter Ruth Anne opens up on her debilitating battle with endometriosis
Exclusive: Ruth Anne Cunningham has penned hits with mega stars including Niall Horan and Britney Spears but told of the agonising pain she was suffering behind the scenes
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Irish songwriter Ruth Anne Cunningham opened up on her battle with endometriosis
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Dubai diaries: No, you needn't embrace pain

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March is Endometriosis Awareness Month.
In 2020, as the tsunami known as Covid-19 hit our lives and confined us to our shells, I found myself on a different battleground. Working from home following a lockdown, I had begun experiencing shooting pain in my lower abdomen. Sometimes, it would be bearable. At other times, I’d feel as though 100 pins were pricking me. When I headed to the doctor’s, I was asked to undergo a few tests, following which the news was broken to me.
“You have endometriosis,” my doctor said. “Endo… what?” I asked, as I reached out for my cell phone. My doctor muttered something, but my gaze was fixed at the Google page that had just opened up. “It is an often painful disorder in which tissue similar to the one that normally lines the inside of your uterus grows outside,” was how Mayo Clinic defined it. “How bad is the pain going to be?” I interjected. My doctor wasn’t willing to sugarcoat anything. The pain would be bad and could get excruciating. Solutions are either laparoscopic surgeries, which do not have a 100 per cent success rate, or popping prescription drugs to relieve pain and manage hormones. It’s been nine months since that diagnosis. Pain has become an albatross that I have no choice but to carry. In the initial months, it put a halt to everything that was important to me.

'I can't get NHS surgery for my excruciatingly painful condition until 2023'


'I can't get NHS surgery for my excruciatingly painful condition until 2023'
Stephanie Leech, 26, was diagnosed with endometriosis in July 2019 but has suffered with it since she was 15
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Stephanie Leech was 15 years old when she started experiencing very painful periods which at times became so severe that they left her bedbound.

Gender stigma needs to be removed to lead to better diagnosis and treatment of endometriosis throughout Australia


Tasmanian Labor
Out of pocket expenses for patients often out of reach
Endometriosis Awareness Month shines much-needed spotlight on illness
The gender stigma associated with the chronic and painful disease endometriosis needs to be broken down to lead to more accurate diagnosis and better treatment of women afflicted with the condition.
Shadow Minister for Women Michelle O’Byrne said Endometriosis Awareness Month presented governments across the nation as well as the medical community with an opportunity to gain a greater understanding of the disease and serious issues around diagnosis and treatment.
“Endometriosis is a common, chronic and debilitating condition that affects 200 million women worldwide and one in nine Australian women,” Ms O’Byrne said.

The conversation about endometriosis and invisible illness has finally reached the arts | Kylie Maslen

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Andi Snelling uses bold, exaggerated movement to illustrate her chronic ill health in Happy-Go-Wrong
Andi Snelling uses bold, exaggerated movement to illustrate her chronic ill health in Happy-Go-Wrong
Sun 14 Mar 2021 22.52 EDT
Last modified on Wed 17 Mar 2021 22.30 EDT
In 2015 a revolt sprung seemingly from nowhere as women began talking openly about chronic, invisible illnesses.
The Guardian Australia journalist Gabrielle Jackson shared her personal experience of endometriosis – the pain, the dismissal by doctors, the impacts on daily life – in a powerful opinion piece. That piece expanded into an international investigation by the Guardian on a condition that had previously received little attention either in the media or among the medical establishment.

Endometriosis and fertility – 6 things all women should know

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Endometriosis can affect infertility and figures show that between 2 - 10% of women have the condition.  However, it is estimated that 60 – 70% of women with endometriosis are fertile and can conceive without any fertility treatment. Endometriosis may be underdiagnosed and women who may have the condition are often categorised as ‘sub-fertile’, meaning that they have reduced fertility potential.
What is endometriosis?
The endometrium is the lining inside the womb.  It is programmed naturally to grow and shed – and that is what happens during menstruation.  Unfortunately, if endometrial tissue forms elsewhere, in the ovaries, for example, there is no way that the tissue can be shed, so it remains and can cause scarring.

Olivia Culpo: Unbearably Painful Endometriosis 'Slowly Took Over' My Life

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Olivia Culpo: Unbearably Painful Endometriosis 'Slowly Took Over' My Life
Celebrity
The former Miss Universe talks about her struggle with endometriosis and how it left her being unable to 'function' due to the excruciating pain she suffered.
Mar 12, 2021
Olivia Culpo's battle with endometriosis "slowly took over" her life.
The model and actress revealed she had been diagnosed with the condition - which causes the uterine lining to grow outside of the uterus - last year (20), and has now opened up on her journey to receiving an official diagnosis, which saw her being repeatedly brushed off by doctors.
"It was getting to the point where not only were my periods becoming unbearable, but then I've learned also that like another symptom of endometriosis as it's progressing is you have pain even in between periods," she told People magazine. "It's not only even when you're on your cycle, it could be in between."

Olivia Culpo Says Endometriosis 'Slowly Takes Over Your Life'

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Model Olivia Culpo says that endometriosis took over her life as she dealt with increasingly painful periods

Apple Study Affirms That Women Have Cramps During Periods

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Photo: Victoria Song/Gizmodo
Apple added period-tracking to the iOS Health app and launched a clinical study into women’s health back in 2019. Now, the Apple Women’s Health Study team has some preliminary data that affirms that, yes, there is an incredible variety of period symptoms suffered by menstruating people worldwide.
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The findings were from the first 10,000 participants who enrolled in the study using the iPhone Research app and provided demographic data. Of that number, 6,141 participants recorded period symptoms and the most commonly tracked were abdominal cramps (83%), bloating (63%), and tiredness (61%). Or, basically, things anyone who’s ever had a period could tell doctors if they just asked. About half the participants also reported acne, headaches, mood swings, appetite changes, lower back pain, and breast tenderness. Some rarer symptoms included diarrhea, sleep changes, constipation, nausea, hot flashes, and ovulation pain.

Dundalk Senator calls for action to be taken to clear waiting lists for endometriosis treatment

Speaking in the Seanad to mark International Women’s Day and Endometriosis Awareness Month, Fianna Fáil Senator Erin McGreehan called for action to...

Why Alexa Chung wants you to know she has endometriosis

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An estimated one in 10 women are affected by endometriosis.

What Is Endometriosis?


Endometriosis is a gynecological condition that occurs when endometrial-like tissue – tissue similar to the type that lines the uterus – grows in areas outside of the uterus, particularly the ovaries and fallopian tubes, bowel, bladder, and pel

UK Government launches call for evidence to improve health and wellbeing of women in England


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UK Government launches call for evidence to improve health and wellbeing of women in England
To mark International Women’s Day, the government is launching a 12-week call for evidence to better understand women’s experiences of the health and care system
All women are urged to share their experiences to form the basis of a new Women’s Health Strategy
The strategy will set an ambitious and positive new agenda to improve health and wellbeing and ensure health services are meeting the needs of women
Launching to coincide with International Women’s Day, the call for evidence will form the basis of a landmark government-led Women’s Health Strategy, to improve the health and wellbeing of women across England and place women’s voices at the centre of their care.

Baring it all to reveal the painful truth

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Endometriosis is often ignored with women expected to get on with their lives — but it needs to be taken seriously, says model Hannah Devane who ...

Mae Whitman Talks About Years of Pain That Led to Endometriosis Diagnosis

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In this week's issue of PEOPLE, the
Good Girls actress, 31, opens up about her years of excruciating pain that led to a life-changing diagnosis, endometriosis — the reproductive condition in which uterine tissue grows outside of the uterus, causing cramping and chronic pain.
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"I remember there was a scene in
One Fine Day where there was a lot of running across New York and I got really sick to the point where I couldn't do it," recalls Whitman, who starred alongside George Clooney and Michelle Pfeiffer in the 1996 romantic drama. "I couldn't keep moving. I remember that kind of marked the beginning of a journey of a lifetime of stomach aches for me, and a lifetime of problems for me."

Kayla Itsines Is Recovering After Her Second Endometriosis Surgery

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Kayla Itsines is on the "very slow" road to recovery after undergoing a second surgery to address her endometriosis.
The fitness influencer, 29, shared on Thursday that she had the surgery on Feb. 19 after living with endometriosis, a painful condition where the uterine lining incorrectly grows outside of the uterus, "for most of my life."
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Itsines said that she went through years of pain before she was able to get her endometriosis diagnosed.
"For me I didn't know if what I was feeling during my periods each month was abnormal," she wrote on Instagram. "It took me years of living with that pain before deciding it wasn't right and going to see a doctor to get the surgical treatment I needed and a confirmed diagnosis."

EXCLUSIVE: Inside endometriosis with Bridget Hustwaite

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From a young age, we’re told that the day we first get our period is the beginning of our journey into adulthood. But for endometriosis battlers, what is supposed to be a monumental day is really the start of a long and arduous health battle. Ask any adult who menstruates and they will still be able to tell you where they were when they first got their period. If not for the fact that the sudden appearance of blood is a memorable occurrence, parents will often liken it to the ‘next chapter’ in our lives, making it a ‘day to remember’.

Forendo Pharma Successfully Completes Phase 1 Studies of FOR-6219 in Endometriosis, Aiming to Advance Program into Phase 2 Clinical Studies


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Forendo Pharma, a clinical-stage drug development company focusing on novel treatments in women's health, today announced the completion of Phase 1 studies in healthy volunteers for its lead development program in endometriosis, FOR-6219, and provided a development outlook. The successfully concluded Phase 1 program demonstrated that FOR-6219, a HSD17B1 enzyme-targeting small-molecule, was safe and well-tolerated and delivered additional results supporting Forendo's therapeutic concept. The company is now planning the Phase 2 program including endometriosis patients in the US.
"The now completed Phase 1 program delivered an initial body of tolerability, safety and pharmacokinetic data. For chronic endometriosis treatment, tolerability and a lack of systemic estrogen deficiency-related side effects are of the utmost importance as we see current therapies struggling to be widely adopted due to their side effect profiles. A local effect on the target tissue with our intracrinology mechanism provides an opportunity for superior management of endometriosis," commented Risto Lammintausta, CEO of Forendo. "We are now looking forward to expanding our clinical development program into the US and potentially into complementary women's health indications, in addition to endometriosis. The upcoming Phase 2 program will transition the clinical evaluation of FOR-6219 into symptomatic patients and deepen our understanding of the drug's impact on the disease biology and endometriotic tissue."

'A Womb Full Of Nails': These Pictures Show The True Pain Of Endometriosis

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Endometriosis sufferers have created a 'pain dictionary' aiming to cut the average 7.5 year wait for diagnosis.

Nicolle Flint MP

Nicolle Flint has been an invaluable member of the Liberal team and my government. Nicolle has been a strong champion for Boothby and South Australia in...

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