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Frontiers | Healthcare Workers in South Korea Maintain a SARS-CoV-2 Antibody Response Six Months After Receiving a Second Dose of the BNT162b2 mRNA Vaccine

Background: Effective vaccines against coronavirus disease 2019 (COVID-19) are available worldwide; however, the longevity of vaccine effectiveness is not known. Objective: We performed a prospective observational study to assess the antibody response of healthcare workers against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after BNT162b2 mRNA COVID-19 vaccination. Methods: SARS-CoV-2 neutralizing antibody (nAb) and spike (S) protein-IgG (S-IgG) antibody titers were examined in participants who received two doses of the BNT162b2 mRNA COVID-19 vaccine in a single center between March 1, 2021, and October 11, 2021. Antibody levels were analyzed at four times: before vaccination (visit 1), 4 weeks after the first vaccination (visit 2), 3 months after the second vaccination (visit 3), and 6 months after the second vaccination (visit 4). Results: A total of 249 healthcare workers at Jeju National University Hospital were enrolled in this study, and 982 blood samples were an ....

Ha Afon , Jeju Island , Cheju Do , South Korea , United States , South Africa , Republic Of Korea , Moreira Ed Jr , Johnson Janssen , Abbot Korea Ltd , Jeju National University Hospital , Large Integrated Health System , Prevention Agency , Department Of Laboratory Medicine , Vaccine Among Us Health Care Personnel , Departments Of Laboratory Medicine , Abbott Ireland Diagnostics Division , Institutional Review Board , Laboratory Medicine , Korean Peninsula , Fully Vaccinated , Supplementary Figure , Korea Disease Control , Abbot Korea , Supplementary Material , Retrospective Cohort ,