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Ecology and Society: Convergent geographic patterns between grizzly bear population genetic structure and Indigenous language groups in coastal British Columbia, Canada

Ecology and Society: Convergent geographic patterns between grizzly bear population genetic structure and Indigenous language groups in coastal British Columbia, Canada
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Fort Collins , United States , University Of Chicago , United Kingdom , Brentwood Bay , British Columbia , Zuid Holland , Slovenia General , Nova Scotia , Hartley Bay , Ocean Falls , Hudson Bay , Monte Carlo , Coahuila De Zaragoza , New York , Province Of British Columbia , University Of Washington , Bella Coola , City Of , Triquet Island , Kyle Artelle , Kate Field , Silva Guimar , Eh Valderrama Sandoval , Gwaii Mclaren , Le Urrego Giraldo ,

Frontiers | Lockdown Learning: Changes in Online Foreign-Language Study Activity and Performance of Dutch Secondary School Students During the COVID-19 Pandemic

Frontiers | Lockdown Learning: Changes in Online Foreign-Language Study Activity and Performance of Dutch Secondary School Students During the COVID-19 Pandemic
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France General , United Kingdom , Satakunta Region , Netherlands General , South Lanarkshire , Noordhoff Uitgevers , Rr Core Team , International Conference On Cognitive Modeling , Loss Due To School Closures , Development Aspects Of Self , University Of Groningen , College Student Motivation , School Closing Period , Geary Institute For Public , Institute For Employment Research , World Bank , Institute For Fiscal , Foundation For Statistical Computing , German High School Students , School Mathematics , Young People Mental Health Symptoms , International Perspective , Efforts Of German High School Students , School Closings , Ethics Committee Psychology , Supplementary Table ,

Long-chain polyphosphates impair SARS-CoV-2 infection and replication

Long-chain polyphosphates impair SARS-CoV-2 infection and replication
sciencemag.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencemag.org Daily Mail and Mail on Sunday newspapers.

United Kingdom , United States , Oxford Nanopore , Autodock Vina , Clustal Omega , Azienda Ospedaliera Universitaria Federico , Napoli Federico , Rr Core Team , Drug Administration , Foundation For Statistical Computing , Prosci Inc , Wyatt Technology , Immunoreagents Inc , Cell Signaling Technology , Agilent Technology , Middle East , Force Covid , Direzione Sanitaria , Dipartimento Di Medicina Molecolare , Biotecnologie Mediche , Hilymaxtransfection Reagent , Graphpad Prism , Thermo Fisher Scientific , Applied Biosystems , Foster City , British United Kingdom ,

Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity

SARS-CoV-2 variants with multiple spike mutations enable increased transmission and antibody resistance. Here, we combine cryo-EM, binding and computational analyses to study variant spikes, including one that was involved in transmission between minks and humans, and others that originated and spread in human populations. All variants showed increased ACE2 receptor binding and increased propensity for RBD up states. While adaptation to mink resulted in spike destabilization, the B.1.1.7 (UK) spike balanced stabilizing and destabilizing mutations. A local destabilizing effect of the RBD E484K mutation was implicated in resistance of the B.1.1.28/P.1 (Brazil) and B.1.351 (South Africa) variants to neutralizing antibodies. Our studies revealed allosteric effects of mutations and mechanistic differences that drive either inter-species transmission or escape from antibody neutralization. ....

New York , United States , United Kingdom , South Africa , Leica Microsystems , Joshua Mendez , Led Eng , Mahira Aragon , Eugene Chua , Rr Core Team , Duke Research Computing , National Institute Of Allergy , Duke Regional Biocontainment Laboratory , Electron Microscopy Sciences , Simons Foundation , Ge Healthcare , National Center , Defense Advanced Projects Agency , National Institutes Of Health , Sera Care Life Sciences , York Structural Biology Center , Common Fund Transformative High Resolution Cryo , Foundation For Statistical Computing , Simons Electron Microscopy Center , Duke University , C Terminal Twinstrep ,

Frontiers | Message Delivery Strategy Influences Willingness to Comply With Biosecurity

Frontiers | Message Delivery Strategy Influences Willingness to Comply With Biosecurity
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New York , United States , Los Angeles County , Los Angeles , Parisit Web , Eric Garcetti , Swine Health , Rr Development Core Team , Yale University Press , Office Of Los Angeles , National Institute Of Food , University Of Vermont , R Foundation For Statistical Computing , Yale University , National Center , Us Department Of Agriculture , City Of Los Angeles Emergency Management Department , Findings Of The National Adult Literacy , Foundation For Statistical Computing , Oreilly Media Inc , Institutional Review Board University Of Vermont , Porcine Reproductive , Respiratory Syndrome , Porcine Epidemic Diarrhea , Numerical Threat Gauge , Linguistic Threat Gauge ,