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Hepatitis E vaccine shows promising 10-year efficacy in the Chinese population

1. Overall vaccine efficacy ranged from 83.1% to 86.6% during the 10-year period. 2. Detectable concentrations of antibodies persisted at the 8.5-year mark in Qindong. Evidence Rating Level: 1 (Excellent) Study Rundown: Hepatitis E virus (HEV) is a leading cause of acute viral hepatitis worldwide. Currently, two recombinant HEV vaccines exist; however, little is known

Qindong , Gansu , China , Dongtai , Jiangsu , Chinese , Rating-level , Between-aug , Dongtai-county , Gastroenterology , Hepatitis

2 Minute Medicine Rewind April 8, 2024 | 2 Minute Medicine

Efficacy and safety of sitagliptin with basal-plus insulin regimen versus insulin alone in non-critically ill hospitalized patients with type 2 diabetes: SITA-PLUS hospital trial 2. Patients randomized to receive and addition of sitagliptin to insulin therapy provided non-critically ill hospitalized patients with type 2 diabetes (T2DM) better glycemic control and higher mean daily glucose level

United-states , American , Brain-cognitive-development-study , American-society-of-anaesthesiologists , Rating-level , American-society , Adolescent-brain-cognitive-development-study , Cardiology , Covid-19 , Diabetes , Diet

Prophylactic pancreatic stent plus indomethacin reduces rates of pancreatitis following endoscopic retrograde cholangiopancreatography

1. Post-ERCP pancreatitis was more common in the indomethacin alone group compared to indomethacin plus stent group. 2. The benefit of stent placement was prominent among patients at high risk for pancreatitis. Evidence Rating Level: 1 (Excellent) Study Rundown: In high-risk patients undergoing endoscopic retrograde cholangiopancreatography (ERCP), combining rectal indomethacin with prophylactic pancreatic stent placement

United-states , Canada , Rating-level , Randomized-trial , Rectal-indomethacin , Between-sept , Acute-pancreatitis , Endoscopic-retrograde-cholangiopancreatography-ercp- , Ercp , Indomethacin , Nonsteroidal-anti-inflammatory-drug-nsaid-

Magnetically guided capsule endoscope with detachable string promising for diagnosing esophagogastric varices

1. In a large prospective multicentre diagnostic accuracy study, magnetically guided capsule endoscopy with a detachable string (ds-MCE) demonstrated high accuracy and safety in the detection and grading of esophagogastric varcies in patients with cirrhosis. Evidence Rating: 1 (Excellent) Esophagogastric varices are highly prevalent in patients with cirrhosis and are a major cause of mortality

Minute-medicine-inc , Cirrhosis , Gastroenterology , Gastrointestinal-bleed , Hepatology , Liver-disease , Emergency ,

2 Minute Medicine Rewind March 11, 2024 | 2 Minute Medicine

Early vs Late Fixation of Extremity Fractures Among Adults With Traumatic Brain Injury 1. In a cohort of patients with traumatic brain injury, early fixation of extremity fractures within 24 hours of injury was not associated with greater rates of unfavourable functional outcomes at 6 months. Evidence Rating: 2 (Good) While extremity fractures are commonly

United-states , Canada , Minute-medicine-inc , Traumatic-brain-injury , Glasgow-outcome-scale-extended , Cancer-screening-trial , Rating-level , Hispanic-black , Better-outcomes-registry , Colon-cancer , Critical-care

Seladelpar improves symptoms of primary biliary cholangitis

1. In this randomized controlled trial, among patients with primary biliary cholangitis (PBC) who had had inadequate response to ursodeoxycholic acid, seladelpar was superior to placebo in achieving biochemical response and symptomatic management. 2. Seladelpar had an acceptable safety profile, with similar rates of adverse events to a placebo. Evidence Rating Level: 1 (Excellent) Study

Minute-medicine-inc , Rating-level , Confidence-interval , Chronic-disease , Gastroenterology , Immunology , Primary-biliary-cholangitis , Seladelpar , Ursodeoxycholic-acid ,

3 GI practices to know

Discover three top gastroenterology practices featured by Becker's in February, including U.S. Digestive Health, Rome Health, and Cedars-Sinai Medical Center.

Pennsylvania , United-states , Rome , Lazio , Italy , Delaware , Aamer-mirza , Melissa-kobito , Rome-health , Us-digestive-health , Us-digestive-health-colmar , Romeny-health

Non-alcoholic fatty liver disease increases cardiovascular and mortality risk in patients with diabetes

1. The risk of cardiovascular disease (CVD) and all-cause death for individuals with type 2 diabetes mellitus (T2DM) is increased for those with non-alcoholic fatty liver disease (NAFLD) compared to those without NAFLD. Evidence Rating Level: 2 (Good) Non-alcoholic fatty liver disease (NAFLD) is increasing in prevalence globally. Patients with NAFLD are at an increased

South-korea , Korea , Minute-medicine-inc , National-health-screening-program-in-korea , Rating-level , National-health-screening-program , Cardiology , Cardiovascular-disease , Diabetes , Hepatology , Nafld

A Multidisciplinary Approach to Managing VOD

Sergio Giralt, MD, leads a discussion on the importance of a multidisciplinary team approach in caring for patients with VOD, from recognizing early signs to treating and monitoring the disease.

Cairo , Al-qahirah , Egypt , Sergio-giralt , York-medical-college , Memorial-sloan-kettering-cancer-center , New-york-medical-college , Memorial-sloan-kettering-cancer , Veno-occlusive-disease , Vod , Multidisciplinary-care-team , Transplant