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Move over, Humira, there's a new mega-blockbuster in town

There was a time not that long ago when Merck & Co. Inc.’s Keytruda (pembrolizumab), with its multiple cancer indications, was seen as the heir apparent to Humira’s title of the biggest blockbuster drug. Not anymore. That title now belongs to Novo Nordisk A/S’ semaglutide, approved as Ozempic in 2017 to treat diabetes and as Wegovy in 2021 to help with weight loss.

Novo-nordisk , Merck-co , Novo-nordiska-s , Semaglutide , Ozempic , Wegovy , Humira , Adalimumab , Keytruda , Merck-amp-co-inc- , Pembrolizumab , Abbvie-inc-

The Weekend

on the d.c. federal charges before the election. so you may end up with a flowery decision about help presidents are not above the law. but the fact, the supreme court would have rendered donald trump immune from this criminal case. >> okay. >> andrew, i did not know you could just say anything. makeup claims like this is what donald trump on hit his site. if the president doesn't have immunity, you can extort or blackmail the president. if the president doesn't have immunity, nothing more than a ceremonial president really having the courage to do what has to be done for the country. the great michael steele tweeted that and said, for 240 years and 45 presidents, this has never been a problem. maybe you are the problem. since when can you makeup claims of immunity and the

Donald-trump , Decision , Election , Fact , Supreme-court , Presidents , Charges , Immune , Law , D-c- , Case , Andrew-wiseman

Interstitial macrophages trigger severe COVID in the lung

SARS-CoV-2 could proliferate in the lungs causing severe COVID-19 through a special type of immune cell. A group of scientists from Stanford University observed how this coronavirus infected interstitial macrophages through a CD209 receptor, triggering the inflammatory response observed in hospitalized patients.

Stanford-university , Bioworld-science , Patents , Coronavirus , Covid-19 , Sars-cov-2 , University-of-california , An-francisco , Severe-covid , Stanford-university-school-of-medicine , Immune

Neuropeptide released by pain neurons promotes wound healing by interacting with immune system

Wound healing is a highly specialized dynamic process for the repair of damaged/injured tissues through an intricate mechanism. Any failure in the normal wound healing process results in abnormal scar formation, and a chronic state which is more susceptible to infections. Researchers from Monash University in Australia and Osaka University in Japan have demonstrated that the removal of a specific subtype of sensory neurons containing the Nav1.8+ ion channel significantly impairs skin wound repair and muscle regeneration following injury.

Monash , South-australia , Australia , Osaka , Japan , Monash-university , Osaka-university , Bioworld-science , Dermatologic , Calcitonin-gene-related-peptide , Cgrp

Biosimilars coming into their own in China, despite concerns

The timing is ripe for a robust biosimilar market in China, given the rapid increase of novel biologics approved to treat cancer and inflammatory diseases in the country over the past decade and the looming patent cliffs for several established biologics. As of December, the NMPA had approved more than 20 biosimilars that were developed in China. Most of those referenced just two biologics – Roche AG’s cancer drug Avastin (bevacizumab) and Abbvie Inc.’s immunology drug Humira (adalimumab). In 2022, the oncology and immunology biosimilar market in China garnered sales of about $2 billion, according to Clarivate estimates. To reach their full potential in China though, biosimilars must win over prescribers and patients.

China , Abbvie-inc , Roche-ag , Avastin , Abbvie-inc- , Humira , Pfizer-inc- , Enbrel , Henlius-biotech-inc- , Hanlikang , Mabthera

Moderna receives a $750M infusion from Blackstone

Blackstone Life Sciences made an investment of up to $750 million in Moderna Inc.’s influenza program created with its mRNA technology. The new funding is designed to help propel the program forward and may help bolster a stock that has struggled in the past 12 months.

Blackstone-life-sciences , Moderna-inc , Moderna-inc- , Influenza , Mrna , Bioworld , Financings , Infection , Vaccine , Mrna-1283 , Covid-19

Australian researchers discover gene mutation that causes psoriasis

Scientists from the Australian National University have discovered the gene mutation responsible for causing psoriasis, and the findings could lead to improved diagnosis and treatment for patients with psoriasis and psoriatic arthritis, a chronic inflammatory skin disease. “We were able to identify the gene that could be important in enabling this progression from a skin-only condition to a skin-and-joint condition,” lead study author Chelisa Cardinez told BioWorld.

Australia , Australian , Chelisa-cardinez , Australian-national-university , Psoriasis , Psoriatic-arthritis , Ikbkb-gene , Nf-κb-signaling-pathway , Dermatologic , Inflammatory , Immune , Bioworld-science

Finding the good in autoantibodies could REAP broad benefits

Autoantibodies call to mind disease – autoimmune disease, to be exact. But the physiological roles of autoantibodies are, at the very least, more complex than this view accounts for. “The autoantibody reactome is extraordinary,” Aaron Ring told BioWorld. “Nearly everyone has autoantibodies, whether they know it or not.”

Bioworld-science , Autoantibodies , Fred-hutchinson-cancer-center , Seranova-bio-inc- , Immune , Antibody , Bioworld , Science ,

AAAS 2024: Chemo brain, other conditions provide lens for long COVID

The biological processes giving rise to the central nervous system symptoms of long COVID remain a mystery. But multiple studies suggest they do not appear to be a result of a direct viral infection of brain tissue. The latest such research, which appeared online in Nature Neuroscience on Feb. 16, 2024, demonstrated that local immune response in brain tissues persisted long after SARS-CoV-2 virus had disappeared.

Nature-neuroscience , Bioworld-science , Long-covid , Sars-cov-2 , Post-covid-syndrome , Aaas-2024 , Infection , Coronavirus , Neurology-psychiatric , Immune , Conferences

Multivalent mRNA vaccine prevents mpox disease

A vaccine based on messenger RNA (mRNA) technology against four surface proteins of the envelope and the inner membrane of the mpox virus (MPXV) demonstrated its efficacy in two animal models. Biontech SE scientists designed and tested two different combinations of antigens in mice and macaques for the two infective forms of the virus. One of them showed better results for its evaluation in clinical trials preventing the disease.

Bioworld-science , Monkeypox , Mpox , Mpox-vaccines , Orthopox-viruses , Biontech-se , Infection , Drug-design , Rug-delivery-and-technologies , Vaccines , Immune