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UConn Research Seeds 17 Projects through New CRISP Funding Initiative

UConn Research Seeds 17 Projects through New CRISP Funding Initiative
uconn.edu - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from uconn.edu Daily Mail and Mail on Sunday newspapers.

University-of-connecticut , Connecticut , United-states , Farmington , School-of-nursing , Hartford-hospital , Megan-anderson , Nkiruka-atuegwu , Jeffrey-hyams , Anthony-vella , Shabnam-lainwalla , Eric-mortensen

UConn Researchers Collaborate with TIP Company Shoreline Biome to Study Microbiome in NICU

UConn Researchers Collaborate with TIP Company Shoreline Biome to Study Microbiome in NICU
UConn researchers recently published their findings on the microbiome of premature infants in the Connecticut Children's NICU, work they completed through a collaboration with TIP company Shoreline Biome.
Shoreline Biome co-founders Tom Jarvie and Mark Driscoll in discussion at their lab, before the COVID-19 pandemic. (Janine Gelineau/UConn Health Photo)
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Bacteria tend to get a bad rap. But oftentimes it’s one bad apple that ruins the reputation of the bunch.
For example,
E. coli, commonly known as bacteria that cause sickness, also has beneficial strains that can help protect us from pathogens. Being able to differentiate between bacterial strains is critical for researchers working to understand the microbiome – the complex environment of bacteria living in and on our bodies.

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Recent Microbiome Study Finds that Shoreline Biome Products Differentiate Closely Related Gut Bacteria in Premature Infants

Recent Microbiome Study Finds that Shoreline Biome Products Differentiate Closely Related Gut Bacteria in Premature Infants
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FARMINGTON, Conn. (PRWEB)
February 18, 2021
Products from Shoreline Biome demonstrated high-resolution tracking of specific bacterial strains in a recent microbiome study, the results of which are being applied to better understand how pathogens and commensals become established in premature infants in neonatal intensive care units (NICU), with the goal of improving outcomes for premature infants.
Shoreline Biome is a microbiome research company based in Farmington that develops tools for characterizing microbiome populations down to the strain level.
The research article, titled "High-Resolution Differentiation of Enteric Bacteria in Premature Infant Fecal Microbiomes Using a Novel rRNA Amplicon," was published February 16, 2021 in mBio. The study describes how Shoreline Biome’s kits and software enable a novel, high-resolution ‘DNA fingerprint’ for bacteria that provides species- and strain-level resolution of the neonatal microbiome. The high-resolution taxonomy obtained from long amplicon sequencing enables the tracking of strains temporally and spatially as microbiomes are established in infants in the hospital environment. “These highly vulnerable infants are at increased risk of developing life-threatening infections.” said Adam Matson, MD (Connecticut Children’s Medical Center and Assistant Professor of Pediatrics and Immunology at UConn Health) “This exciting new approach represents a major technical advancement in the classification of intestinal microbiota and will enable source-tracking of pathogenic and beneficial microbes in the NICU.”

University-of-connecticut , Connecticut , United-states , Farmington , Joerg-graf , Mark-driscoll , Eric-jackson , Adam-matson , Connecticut-children-medical-center , Md-connecticut-children-medical-center , Uconn-health , Shoreline-biome