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Overlooked Covalent Crosslink an On/Off Switch for Proteins Protein structure showing a newly identified crosslink, one between a cysteine residue and a lysine residue. (Electron densities are indicated in yellow.) The crosslink has wide-reaching implications for the engineering of proteins, the unraveling of disease mechanisms, and the development of new drugs. [Kai Tittmann University of Göttingen] May 5, 2021 Share Make room, disulfide crosslinks. There’s a new kind of crosslink in proteins. Instead of an S–S bridge connecting two cysteine residues, it consists of an N–O–S bridge...

 E-Mail IMAGE: Protein structure with the newly identified switch between a cysteine and lysine residue showing its structure and electron density. This discovery has wide-reaching implications for understanding and treating diseases. view more  Credit: K Tittmann Proteins perform a vast array of functions in the cell of every living organism with critical roles in almost every biological process. Not only do they run our metabolism, manage cellular signaling and are in charge of energy production, as antibodies they are also the frontline workers of our immune system fighting human...