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AAA Technologies, Exicom Tele-Systems, NGL Fine Chem, Just Dial and Bhagiradha Chem, hit their fresh 52-week highs during the day.
The Nifty Pharma index closed 0.91 per cent down at 18525.75.
The Nifty IT index was trading 0.0 per cent at 35292.0.
The Nifty Pharma index was trading 0.62 per cent down at 18997.8.
Sun Pharma, Titan Company, Shriram Finance, Maruti Suzuki and JSW Steel were among the top losers on NSE.