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Spike protein-human cell binding mechanism holds clue to Covid drugs, IIT Madras study claims According to the study, understanding spike protein interactions at ACE2 receptor site in humans will help find ways to reduce severity of coronaviruses and treatment options. Soniya Agrawal 27 April, 2021 8:17 am IST A+ New Delhi: The reason for the devastating transmission and infection of Covid-19, as compared to common-cold causing coronaviruses, is due to the high interaction energy and area between the spike protein of the SARS-CoV-2 virus and the human ACE2 receptor protein, seen as the entry point for the coronavirus to hook onto and infect a wide range of human cells, a study by IIT Madras has found. ....
IIT-Madras studying Coronavirus high transmission potential By IANS | 2 Views Indian Institute of Technology Madras. Image Source: IANS News Chennai, April 26 : The Indian Institute of Technology Madras researchers are studying the high transmission rate and mortality of SARS-CoV-2, the scientific name for the coronavirus that causes Covid-19. Using computational tools, the team studied its two close variants SARS-CoV and NL63. SARS-CoV can be considered a asibling of the subfamily beta coronavirus aSARS-CoV-2 , while the aNL63 belongs to sub-family alpha coronavirus and can be considered as a acousin of SARS-CoV-2. SARS-CoV is more severe than SARS-CoV-2, whereas NL63 shows milder symptoms than SARS-CoV and SARS-CoV-2. ....
Share Chennai: Indian Institute of Technology Madras researchers are studying the high transmission rate and mortality of SARS-CoV-2, the scientific name for the coronavirus that causes COVID-19. Using computational tools, the team studied its two close variants – SARS-CoV and NL63. The team set out to understand how the spike proteins (which enables the coronavirus to penetrate human cells and cause COVID-19) of these different virus strains are interacting with the ACE2 receptors of human cells and how this interaction is affecting their transmission potential and severity of the disease ‘SARS-CoV’ can be considered a ‘sibling’ of the subfamily beta coronavirus ‘SARS-CoV-2.’ The ‘NL63’ belongs to sub-family alpha coronavirus can be considered as a ‘cousin’ of SARS-CoV-2. SARS-CoV is more severe than SARS-CoV-2 whereas NL63 shows milder symptoms than SARS-CoV and SARS-CoV-2. ....
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