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Conventional vaccines usually contain antigens – components of the respective pathogens – that bind to receptors on the surface of their target cells in order to trigger the disease. Scientists at the Berlin Institute of Health at Charité (BIH) and the Max Delbrück Center have now discovered that antigen variants with low receptor binding can be advantageous for the development of vaccines. The research team has succeeded in producing a new vaccine against the SARS-CoV-2 coronavirus by identifying spike protein mutants that lack binding affinity. The scientists have now published their f...

Multiple sclerosis (MS) can take many different forms, which is why it is sometimes called “the disease of a thousand faces.” MS is also complex and difficult to treat. Now, an international consortium headed by Charité – Universitätsmedizin Berlin a

The mucus in the airways is not as sticky, inflammation in the lungs significantly reduced: Triple combination therapy can achieve these positive, lasting effects in patients with cystic fibrosis (CF). Researchers from Charité – Universitätsmedizin B

Alzheimer's is considered a disease of old age, with most people being diagnosed after 65. But the condition actually begins developing out of sight many years before any symptoms emerge.

The Arl8b protein provides new insights into the mechanisms underlying Alzheimer’s disease. It also has the potential to function as a diagnostic marker. The scientists behind this discovery, a team led by Erich Wanker from the Max Delbrück Center, have published their findings in “Genome Medicine”.