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Study: Development of tools, techniques to explore tumor microenvironment

The researcher is aiming to improve the odds for these patients in two recent studies that are primarily concerned with understanding why and how people respond differently to disease and therapies. ....

United States , Emory University , Ahmet Coskun , Georgia Tech , Precision Oncology , Biomedical Engineering , Ews India ,

Oncomatryx Announces FDA and AEMPS IND Clearance for OMTX705, a First-in-class Tumor Microenvironment-targeted ADC, to Treat Advanced Solid Tumors

After 15 years of pioneering R&D efforts in the tumor microenvironment, Oncomatryx announces that the FDA and the Spanish Drug Agency (AEMPS) have cleared its investigational new drug (IND) application ....

United States , Pedro Esnaola , Kostenloser Wertpapierhandel , Spanish Drug Agency , Institute Of Cell Biology , Immunology Of The University Stuttgart Germany , Bizkaia Technology Park Bilbao , Cancer Associated Fibroblasts , Bizkaia Technology Park , Cell Biology ,

Cancer Immunotherapy Modulates Tumor Immunophenotype

Small-molecule activation of innate immunity induces the infiltration of immune cells into cancer cells, as per new research. ....

Innate Immunity , Ancer Immunotherapy , Cold Tumors , Lot Tumors ,

Characterization of immune cell phenotypes

The HALO image analysis platform with HiPlex v2 can quantify RNA expression and distinct cell phenotypes ....

Rnascope Hiplex , Application Note , Advanced Cell Diagnostics , Cell Phenotype , Rna Expression , Ene Expression , Dna Quantification ,

"Overcoming microenvironment-mediated chemoprotection through stromal g" by Somayeh S. Tarighat, Fei Fei et al.

Environmentally-mediated drug resistance in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) significantly contributes to relapse. Stromal cells in the bone marrow environment protect leukemia cells by secretion of chemokines as cues for BCP-ALL migration towards, and adhesion to, stroma. Stromal cells and BCP-ALL cells communicate through stromal galectin-3. Here, we investigated the significance of stromal galectin-3 to BCP-ALL cells. We used CRISPR/Cas9 genome editing to ablate galectin-3 in stromal cells and found that galectin-3 is dispensable for steady-state BCP-ALL proliferation and viability. However, efficient leukemia migration and adhesion to stromal cells are significantly dependent on stromal galectin-3. Importantly, the loss of stromal galectin-3 production sensitized BCP-ALL cells to conventional chemotherapy. We therefore tested novel carbohydrate-based small molecule compounds (Cpd14 and Cpd17) with high specificity for galectin-3. Consistent with results obtai ....

B Cell Precursor All , Arbohydrate Based Galectin 3 Inhibitor , Drug Resistance , Alectin 3 ,