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Early Release - Tula Virus as Causative Agent of Hantavirus Disease in Immunocompetent Person, Germany - Volume 27, Number 4—April 2021 - Emerging Infectious Diseases journal


Hantaviridae, genus
Microtus arvalis) (
2). TULV, a broadly distributed virus in different parts of Eurasia, is hosted by common voles but has also been found in related vole species (
3). Clinical findings of TULV pathogenicity are very rare. In 2003, a case of TULV-associated hantavirus disease was diagnosed by serologic and molecular epidemiologic means (
4). So far, direct molecular evidence for TULV infection has only been found in 2 cases (1 in an immunocompromised patient who had severe hantavirus disease [
5], the other in an immunocompetent person without preexisting illness who had mild hantavirus disease [
We report molecular evidence of TULV infection in a 21-year old immunocompetent man who originated from a small village near Hamburg, northern Germany. He was admitted to hospital for sudden fever, sickness, severe headache, abdominal pain, and limb pain since the day before. His medical history was unremarkable. The patient worked as a sanitary and heating engineer in the northern part of Germany. Except for elevated body temperature, the physical examination did not reveal any abnormalities. Blood testing at the day of admission revealed thrombocytopenia (63 platelets/nL), markedly elevated C-reactive protein (63.6 mg/L), and borderline leukocyte (9.8 cells/nL) and serum creatinine (1.2 mg/dL) values. Because of biochemical signs of infection, ultrasound findings of a moderate enlargement of spleen and cervical lymph nodes as well as hints of a small lung infiltration, an antibiotic regime (ampicillin/sulbactam and clarithromycin) was initiated. Over the next few days, the fever resolved.

Germany , Seoul , Soult-ukpyolsi , South-korea , Hamburg , Schleswig , Schleswig-holstein , Czech-republic , Poland , Belgrade , Serbia-general ,