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Organoids reveal how to protect the brain against dementia and ALS following traumatic injury, according to study

Organoids reveal how to protect the brain against dementia and ALS following traumatic injury, according to study
sciencedaily.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencedaily.com Daily Mail and Mail on Sunday newspapers.

New-york , United-states , Jesse-lai , Zhen-zhao , Joshua-berlind , Violeta-yu , Russell-jacobs , Justin-ichida , Jean-paul-urenda , Gabriella-fricklas , Department-of-defense , York-stem-cell-foundation

ARPA-H Awards Columbia Researchers Nearly $39M to Develop a Living Knee Replacement

ARPA-H Awards Columbia Researchers Nearly $39M to Develop a Living Knee Replacement
columbia.edu - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from columbia.edu Daily Mail and Mail on Sunday newspapers.

New-york , United-states , Columbia-university , Americans , Joanna-smeeton , X-edward-guo , Roshan-shah , Chang-lee , Holly-evarts , Roberte-carroll , Steve-thomopoulos , Gerard-ateshian

Columbia researchers secure $38.95 million ARPA-H contract to build a living knee replacement

A team of researchers from Columbia University Irving Medical Center and Columbia Engineering has been awarded up to a $38.95 million contract from the Advanced Research Projects Agency for Health (ARPA-H) to build a living knee replacement from biomaterials and human stem cells, including a patient's own cells.

Columbia-university , New-york , United-states , Americans , Treena-arinzeh , Kam-leong , Rachelc-shelton , X-edward-guo , Roshan-shah , Helen-lu , Roberte-carroll , Mildred-embree

STEM teachers who 'want to be there' for students honored

STEM teachers who 'want to be there' for students honored
thechiefleader.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from thechiefleader.com Daily Mail and Mail on Sunday newspapers.

City-of-new-york , New-york , United-states , East-harlem , Plattsburgh , Rhode-island , Bamako , Mali , Brown-university , Columbia-university , Malian , American

Common household chemicals pose new threat to

<p>A team of researchers from the Case Western Reserve University School of Medicine has provided fresh insight into the dangers some common household chemicals pose to brain health. They suggest that chemicals found in a wide range of items, from furniture to hair products, may be linked to neurological diseases like multiple sclerosis and autism spectrum disorders.</p>


New-york , United-states , Mayur-madhavan , Marissa-scavuzzo , Kristin-lee , Erin-cohn , Ruth-weber-goodman , Benjamin-clayton , Sara-yacoub , Katie-paul-friedman , Paul-tesar , Yuriy-fedorov

Study reveals genetic variant linked to increased risk of leukemia in Hispanic/Latino children

Acute lymphoblastic leukemia (ALL), the most common childhood cancer, disproportionately affects children of Hispanic/Latino origin in the United States.

San-francisco , California , United-states , Boston , Massachusetts , China , Stanford-university , Dana-farber-cancer-institute , Berkeley , Jun-yang , Jiangxi , Guangzhou

USC researchers find genetic variant contribu

<p style="text-align:start">Children of Hispanic/Latino origin are 30-40% more likely to get Acute lymphoblastic leukemia (ALL) than non-Hispanic white children. However, the exact genetic basis and cause of that increased risk are unknown. Now researchers have revealed a key genetic variant contributing towards the increased risk, as well as details about the biological basis of ALL.&nbsp;The research team focused on the&nbsp;<em>IKZF1&nbsp;</em>gene, known to relate to ALL but never before linked with ethnic risk disparities. Using genetic fine-mapping analysis, they independently analyzed each position along the gene&mdash;known as a single nucleotide polymorphism (SNP)&mdash;to determine whether having a certain variant increased ALL risk. They found three independent SNPs linked to higher ALL incidence, one of which was present in about 30% of people of Hispanic/Latino origin in the U.S. and less than 1%&nbsp;&nbsp;of people of primarily European origin. Although overall risk for the disease is low across all racial/ethnic groups, children with that gene variant, located at SNP rs76880433, were 1.44 times as likely to develop ALL as children without the variant.&nbsp;They also found that the risk variant reduced chromatin accessibility, preventing&nbsp;<em>IKZF1&nbsp;</em>proteins from being fully expressed. In experiments with stem cells, the team found that &ldquo;knocking out&rdquo; the&nbsp;<em>IKZF1&nbsp;</em>gene caused B-cell development to stall in its early stages.</p>

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New-york , United-states , Donglei , Jiangsu , China , Dana-farber-cancer-institute , Massachusetts , California , Jun-yang , Jiangxi , Stanford-university , Boston

Ancient DNA reveals origin of racial/ethnic d

<p>Hispanic/Latino individuals have the highest risk of acute lymphoblastic leukemia (ALL) in the United States. &nbsp;However, the basis for this difference is not well understood. Researchers recently identified a genetic variant that accounts for the increased risk of B-cell ALL in Hispanic/Latino children, and using ancient DNA, they traced the mutation all the way back to the first migrants who entered the Americas ~13,000 years ago.&nbsp;The findings were published in <em>Cell Genomics</em> on March 26.</p>


Montana , United-states , Argentina , Mexico , New-york , Boston , Massachusetts , American , America , Lara-wahlster , Vijay-sankaran , University-of-southern-california

Ancient DNA Unveils Racial Disparity Roots in Child Cancer

Ancient DNA Unveils Racial Disparity Roots in Child Cancer
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

New-york , United-states , Argentina , Boston , Massachusetts , Mexico , Montana , America , American , Lara-wahlster , Vijay-sankaran , Blood-disorders-center

Common household chemicals pose new threat to brain health, study finds

Common household chemicals pose new threat to brain health, study finds
sciencedaily.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencedaily.com Daily Mail and Mail on Sunday newspapers.

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