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Brain's 'wiring insulation' is one of major factors of age-related brain deterioration

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Brain’s ‘wiring insulation’ is one of major factors of age-related brain deterioration
A new study led by the University of Portsmouth has identified that one of the major factors of age-related brain deterioration is the loss of a substance called myelin.
Myelin acts like the protective and insulating plastic casing around the electrical wires of the brain – called axons. Myelin is essential for superfast communication between nerve cells that lie behind the supercomputer power of the human brain.
The loss of myelin results in cognitive decline and is central to several neurodegenerative diseases, such as Multiple Sclerosis and Alzheimer’s disease. This new study found that the cells that drive myelin repair become less efficient as we age and identified a key gene that is most affected by ageing, which reduces the cells ability to replace lost myelin.

Germany , Italy , Milan , Lombardia , United-kingdom , Switzerland , Italian , Swiss , Andrea-porzionato , Andrea-rivera , Kasum-azim , Emma-gray

Scientists awarded £1.2 million to design Parkinson's drug

Researchers from the University of Sheffield's Institute of Translational Neuroscience (SITraN) have been awarded over £1 million from Parkinson's UK to...

United-kingdom , Heather-mortiboys , University-of-sheffield-sitra , University-of-sheffield , Translational-neuroscience , Virtual-biotech , United-kingdom-senior-fellowship , United-kingdom-drug-discovery , Senior-lecturer , University , Sheffield , Uk

Blending old and new to fight pancreatic cancer

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Blending old and new to fight pancreatic cancer
Kanazawa, Japan – Bertolt Brecht, the German playwright, famously said, “Mixing one’s wines may be a mistake, but old and new wisdom mix admirably.” Now, researchers at Kanazawa University have shown that a combination of innovative immunomodulation with traditional chemotherapy may prove efficacious in combatting metastatic cancer of the pancreas.
Pancreatic cancer is a dreaded malignancy, the commonest variant being pancreatic ductular adenocarcinoma (PDAC). Most patients present in advanced stages, with only about a fifth amenable to curative surgery at diagnosis. Conventional chemotherapy involves the drug Gemcitabine (GEM) but, unfortunately, the outcome is often bleak.

Germany , Japan , Japanese , German , Shuichi-kaneko , Alessandro-nasti , Takuya-komura , Takashi-wada , Bertolt-brecht , Yoji-kitamura , Eishiro-mizukoshi , Tatsuya-yamashita

Future of Rare Disease Research: Ethics, Treatments, and Access

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Future of Rare Disease Research: Ethics, Treatments, and Access
PHILADELPHIA- In celebration of the 10th Anniversary of the Orphan Disease Center, pioneering gene therapy scientist James Wilson, MD, PhD, a professor and director of the Penn Gene Therapy Program and the Penn Orphan Disease Center at the Perelman School of Medicine (PSOM) at the University of Pennsylvania, will lead a two-day symposium, featuring former Prime Minister of the United Kingdom and rare disease parent David Cameron and National Institutes of Health Director Francis Collins, MD, PhD, among many others. The event will take place on Wednesday, February 24th and Thursday, February 25th.

United-kingdom , Francis-collins , Janet-woodcock , Lynn-barghout-jafar , James-wilson , David-cameron , Michaels-brown , Penn-orphan-disease-center , University-of-texas-southwestern , National-institutes-of-health , Anniversary-of-the-orphan-disease-center , Drug-administration

$1.2 million to find new treatment for rare cancer

The team will explore the underlying molecular cause of mesenteric fibrosis, as well as develop new diagnostic and imaging tools to treat the condition ...

Amsterdam , Noord-holland , Netherlands , Martyn-caplin , Chrissie-thirlwell , University-of-exeter-medical-school , University-college-london , Exeter-university , Neuroendocrine-tumor-research-foundation , Erasmus-university-medical-center , University-of-exeter , Collaborative-petersen-accelerator-award