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WASHINGTON — Tranexamic acid administered intravenously before and after noncardiac surgery lowered the risk for life-threatening, major and critical organ bleeding compared with placebo, according to results of the POISE-3 trial.Although 1 g IV bolus tranexamic acid cut bleeding risk at 30 days, noninferiority was not established for the composite vascular outcome compared with placebo,
Convalescent plasma, when administered within 9 days of symptom onset in patients with COVID-19, may reduce the risk for hospitalization, according to data published in The New England Journal of Medicine. “While everyone was focused on treating people in the hospital after progression of disease, we saw the need to keep people out of the hospital rather than wait until they were near
The amygdala, which is enlarged in children aged 2 years who are diagnosed with autism spectrum disorder, appears to accelerate in growth in the first 6 to 12 months of life, researchers reported in The American Journal of Psychiatry. “This suggests that early, presymptomatic brain changes in infancy may represent a cascade of linked brain and behavior changes that lead to the emergence of
Iberdomide, a novel oral cereblon modulator, was superior to a placebo only in patients with systemic lupus erythematosus who received the highest dose in a phase 2 trial, albeit with a high incidence of adverse events, according to data.
The COVID-19 pandemic substantially affected the pediatric oncology workforce, leading to physical, psychological and financial strain, according to results of a survey study published in Cancer. “This survey is unique, as it captures the global impact of the pandemic in the context of a discipline, ie, pediatric hematology/oncology,” Lorena V. Baroni, MD, of the hematology/oncology