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New Method Holds Potential to Fight Botulinum Toxin by Angela Mohan on  January 7, 2021 at 3:23 PM Science Translational Medicine by Patrick McNutt, PhD, of the Wake Forest Institute for Regenerative Medicine. Furthermore, in a companion article, an independent team demonstrated that a related drug has robust efficacy in mice. "This is one of those serendipitous moments in science where two groups, working independently, demonstrate similar results for a long-standing problem," McNutt said. "We are currently modifying this drug to enhance its therapeutic properties against ...

Non-toxic versions of botulism toxins can deliver therapeutic antibodies to treat botulism Taking advantage of the chemical properties of botulism toxins, two teams of researchers have fashioned non-toxic versions of these compounds that can deliver therapeutic antibodies to treat botulism, a potentially fatal disease with few approved treatments. The research, which was conducted in mice, guinea pigs, and nonhuman primates, suggests that the toxin derivatives could one day offer a platform to quickly treat established cases of botulism and target hard-to-reach molecules within neurons. Botul...

 E-Mail IMAGE: Schematic showing how the chimera molecule (BoNT/XA) delivers nanobodies to neurons to neutralize botulism neurotoxins. This material relates to a paper that appeared in the Jan. 6, 2021, issue of... view more  Credit: [Credit: S.-I. Miyashita et al., Science Translational Medicine (2021)] Taking advantage of the chemical properties of botulism toxins, two teams of researchers have fashioned non-toxic versions of these compounds that can deliver therapeutic antibodies to treat botulism, a potentially fatal disease with few approved treatments. The research, which was...

Related to new research published in the January issue of Science Translational Medicine, Patrick McNutt, PhD, of the Wake Forest Institute for Regenerative Medicine, was part of the research team that demonstrated a new "Trojan horse" approach that produces strong antidotal efficacy in treating lethal botulism in mice, guinea pigs and rhesus macaque monkeys. Furthermore, in a companion article, an independent team demonstrated that a related drug has robust efficacy in mice. "This is one of those serendipitous moments in science where two groups, working independently, demonstrate similar ...