Voriconazole, Amphotericin B and Natamycin for Keratitis
6 Similarly, intrastromal Amphotericin-B (ISAMB) has also been employed successfully for targeted drug delivery. 7 In an experimental study in rabbit eyes by Mimouni et al, intrastromal natamycin (ISNTM) was employed successfully for treatment of Fusarium keratitis. 8 While many studies have individually described the utility of these drugs for intrastromal injections in recalcitrant fungal keratitis, there is a relative paucity of peer-reviewed literature prospectively comparing the safety and efficacy of these drugs. We conducted a randomized clinical trial to determine and compare the saf...
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