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It can be uncomfortable. it can lead to panic attacks or anxiety attacks in people. >> how do you know when you've done too much? >> simple tasks become very frustrating, like mixing paint, and then just sort of get into this state of, you know -- >> and why that happens is exactly what columbia university neuroscientist carl hart is investigating. >> exhale. >> research subjects in his lab smoke marijuana and then take a variety of cognitive tests. >> the effects will be disruption in memory, disruptions in inhibitory control. they will become slower at cognitive functioning, a wide range of ...

>> how do you know when you've done too much? >> simple tasks become very frustrating, like mixing paint, and then just sort of get into this state of, you know -- >> and why that happens is exactly what columbia university neuroscientist carl hart is investigating. >> exhale. >> research subjects in his lab smoke marijuana and then take a variety of cognitive tests. >> the effects will be disruption in memory, disruptions in inhibitory control. they will become slower at cognitive functioning, a wide range of things. these effects are temporary, but they're pretty pronounced, and they are cle...

Started unless i got high. >> joel vargas started smoking when he was just 13. by 15 he was smoking more than a dozen times a day. he stopped skateboarding. he even dropped out of school. >> i like getting high. i need to get high because my brain is telling me. >> adolescents starting about age 13 have a pretty mature brain reward center. so they can experience rewards and pleasures the same way adults can, but the problem with that is that their prefrontal cortex, which helps people think ahead, control their impulses, that's not fully developed until age 24. that explains why adolescents ar...

>> simple tasks become very frustrating, like mixing paint, and then just sort of get into this state of, you know -- >> and why that happens is exactly what columbia university neuroscientist carl hart is investigating. >> exhale. >> research subjects in his lab smoke marijuana and then take a variety of cognitive tests. >> the effects will be disruption in memory, disruptions in inhibitory control. they will become slower at cognitive functioning, a wide range of things. these effects are temporary, but they're pretty pronounced, and they are clear. >> and it's slowly becoming clear to scien...

>> simple tasks become very frustrating, like mixing paint, and then just sort of get into this state of, you know -- >> and why that happens is exactly what columbia university neuroscientist carl hart is investigating. >> exhale. >> research subjects in his lab smoke marijuana and then take a variety of cognitive tests. >> the effects will be disruption in memory, disruptions in inhibitory control. they will become slower at cognitive functioning, a wide range of things. these effects are temporary, but they're pretty pronounced, and they are clear. >> and it's slowly becoming clear to scien...