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AI-driven research identifies pulmonary fibrosis target and inhibitor

Deep learning algorithms have enabled the discovery of molecular structures of interest in biomedicine to design treatments against aggressive diseases such as idiopathic pulmonary fibrosis (IPF). Scientists at Insilico Medicine Inc. selected a target for IPF using artificial intelligence (AI), then designed an inhibitor to block it, and tested it in vitro, in vivo, and in clinical trials.

Scientists-at-insilico-medicine-inc , Insilico-medicine , Bioworld-science , Respiratory , Insilico-medicine-inc- , Idiopathic-pulmonary-fibrosis , Tnik , Tnik-inhibitors , Artificial-intelligence , Drug-design , Rug-delivery-and-technologies

Rapt slapped with phase II hold on CCR4 prospect

On the verge of top-line data from its phase IIb trial with oral small-molecule CC chemokine receptor 4 (CCR4) antagonist zelnecirnon in atopic dermatitis (AD), due around the middle of this year, Rapt Therapeutics Inc. said the U.S. FDA has imposed a clinical hold on that study with the otherwise promising drug, also known as RPT-193, in AD as well as the phase IIa trial with the same compound in asthma.

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Delhi Air Pollution: National CapitalтАЩs Poor Air Quality Spikes Respiratory, Cardiac Problems, Say Doctors

“The primary contributing factor to these health issues is the presence of smog, which directly irritates the lungs and throat, particularly affecting those with pre-existing respiratory conditions,” she explained.

📰 Delhi Air Pollution: National Capital’s Poor Air Quality Spikes Respiratory, Cardiac Problems, Say Doctors.

Manipal , Karnataka , India , Delhi , New-delhi , Dwarka , Gujarat , Puneet-khanna , Anshum-aneja-arora , Sushila-kataria , Gas-chamber , National-capital-turns

23 states where virus activity remains high

CDC data shows downward trend in respiratory virus visits to ERs, but overall activity remains elevated. Some states still experiencing high levels, while majo

Colorado , United-states , New-hampshire , Mississippi , Massachusetts , Wyoming , Louisiana , South-carolina , New-mexico , Georgia , Oklahoma , Rhode-island

18 states where virus activity is still high

18 states where virus activity is still high
beckershospitalreview.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from beckershospitalreview.com Daily Mail and Mail on Sunday newspapers.

Texas , United-states , Arkansas , Wyoming , Ohio , Louisiana , Kentucky , New-mexico , Colorado , New-jersey , South-carolina , Massachusetts

Scientists identify a pathway for lung repair after viral infection

A common molecular pathway associated with lung fibrosis may also hold the key to pulmonary vascular repair. A group of scientists at the University of Pennsylvania (Penn) found that when a viral infection damaged these vessels, the injury could be restored by activating the transforming growth factor-β receptor 2 (TGF-βR2) in endothelial cells, which led to cell proliferation.

University-of-pennsylvania-penn , Bioworld-science , Respiratory , University-of-pennsylvania , Influenza , Sars-cov-2 , Tgf-β , Endothelial-cells , Tgf-βr2 , Lung-repair , Infection

Gut microbiome may hold key to fighting common respiratory viruses

The composition of microbiota found in the gut influences how susceptible mice are to respiratory virus infections and the severity of these infections, according to researchers from the Center for Translational Antiviral Research in the Institute for Biomedical Sciences at Georgia State University.

Georgia , United-states , University-of-georgia , Georgia-state-university , Michal-kuczma , Carolinm-lieber , Vul-ngo , Richard-plemper , Andrew-gewirtz , Kaori-sakamoto , Translational-antiviral-research-at-georgia , Institute-for-biomedical-sciences

Philips consent decree with FDA will halt sales of sleep apnea devices

Royal Philips NV agreed with the U.S. FDA to the terms of a consent decree focused on its Respironics business, following the recall of millions of its devices over the last few years. Although the details of the decree are being finalized, Philips said it will halt the sales of new continuous positive airway pressure (CPAP) and bilevel positive airway pressure (BiPAP) sleep therapy machines as well as other respiratory care devices in the U.S. until the conditions of the decree are met.

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