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TGen looks beyond COVID-19 as it advances pathogen sequencing

TGen looks beyond COVID-19 as it advances pathogen sequencing
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Phoenix , Arizona , United-states , Taiwan , Massachusetts , David-engelthaler , Steve-yozwiak , Dan-calvo , Tgen-megan-folkerts , Genomics-union , Us-centers-for-disease , Arizona-department-of-health-services

Like priming a pump, cells damaged by chronic lung disease can result in severe COVID

Like priming a pump, cells damaged by chronic lung disease can result in severe COVID
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

Phoenix , Arizona , United-states , United-kingdom , Brompton , Medway , Harefield , Hillingdon , London , City-of , Edinburgh , Jonathan-kropski

TGen identifies gene that could help prevent or delay onset of Alzheimer's disease

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PHOENIX, Ariz. -- April 13, 2021 -- Findings of a study by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, suggest that increasing expression of a gene known as ABCC1 could not only reduce the deposition of a hard plaque in the brain that leads to Alzheimer's disease, but might also prevent or delay this memory-robbing disease from developing.
ABCC1, also known as MRP1, has previously been shown in laboratory models to remove a plaque-forming protein known as amyloid beta (Abeta) from specialized endothelial cells that surround and protect the brain and cerebral spinal cord. Building on previous studies, TGen conducted a series of pre-clinical genomic laboratory experiments. Results suggest that ABCC1 not only could export Abeta out of the brain, but that increasing the expression of ABCC1 could reduce Abeta production, thus preventing, or delaying, the onset of Alzheimer's.

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New study predicts changing Lyme disease habitat across the West Coast

New study predicts changing Lyme disease habitat across the West Coast
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TGen seeks help from Arizona dog and cat owners for COVID-19 study

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IMAGE: Hayley Yaglom, TGen genomic epidemiologist and lead researcher on a project to test pets for COVID-19, takes a blood sample from a dog.
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Credit: Photo: Courtesy of TGen.
PHOENIX, Ariz. -- March 10, 2021 -- The Translational Genomics Research Institute (TGen), an affiliate of City of Hope, announced today the start a new scientific study: Testing pets of those Arizonans who have contracted COVID-19.
No pets will be harmed during this study as all sample collections will be performed by trained veterinary staff. Among the more than 120 pets that have tested positive nationwide, there is no evidence suggesting that pets can spread the virus to humans.

Phoenix , Arizona , United-states , Spain , David-engelthaler , Steve-yozwiak , Hayley-yaglom , Us-centers-for-disease , Linkedin , Arizona-department-of-health-services , Tgen-one-health , Translational-genomics-research-institute-tgen

TGen-led study confirms cell-free DNA in urine as potential method for cancer detection

TGen-led study confirms cell-free DNA in urine as potential method for cancer detection
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

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Exact Sciences to Acquire Ashion Analytics and Enter Research Collaboration with City of Hope's Genomics Institute, TGen

Exact Sciences to Acquire Ashion Analytics and Enter Research Collaboration with City of Hope's Genomics Institute, TGen
Provides Access to Industry-Leading Sequencing Lab and Plans for 10-Year Partnership with National Cancer Research Leaders
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(PRNewsfoto/EXACT SCIENCES CORP)
(PRNewsfoto/EXACT SCIENCES CORP)
MADISON, Wis., Feb. 16, 2021 /PRNewswire/ -- Exact Sciences Corp. (Nasdaq: EXAS) today announced that it has entered into an agreement to acquire Ashion Analytics, LLC (Ashion) from The Translational Genomics Research Institute (TGen), an affiliate of City of Hope. Ashion is a CLIA-certified and CAP-accredited sequencing lab based in Phoenix, Arizona with the genomics testing capabilities necessary to address the increasingly complex needs of clinical, academic, and biopharma customers focused on precision cancer treatments. The team at Ashion will help accelerate the development of Exact Sciences' precision oncology portfolio, including minimal residual disease (MRD) and other sequencing-based tests.

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TGen-led study results suggest more accurate diagnostic for breast cancer

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PHOENIX, Ariz. -- Jan. 26, 2021 -- Breast cancer, even at its initial stages, could be detected earlier and more accurately than current techniques using blood samples and a unique proteomics-based technology, according to findings of a study led by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope.
Patrick Pirrotte, Ph.D., an Assistant Professor and Director of TGen's Collaborative Center for Translational Mass Spectrometry, and an international team of researchers developed a test that can detect infinitesimally small breast cancer biomarkers that are shed into the bloodstream from cells surrounding cancer known as extracellular matrix (ECM), according to the findings of their study recently published in the scientific journal

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Study results show COVID-19 virus triggers antibodies from previous coronavirus infections

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The results of a study led by Northern Arizona University and the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, suggest the immune systems of people infected with COVID-19 may rely on antibodies created during infections from earlier coronaviruses to help fight the disease.
COVID-19 isn't humanity's first encounter with a coronavirus, so named because of the corona, or crown-like, protein spikes on their surface. Before SARS-CoV-2 -- the virus that causes COVID-19 -- humans have navigated at least 6 other types of coronaviruses.
The study sought to understand how coronaviruses (CoVs) ignite the human immune system and conduct a deeper dive on the inner workings of the antibody response. The published findings, "Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronaviruses," appear today in the journal Cell Reports Medicine.

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TGen-NAU study: COVID-19 virus triggers antibodies from previous coronavirus infections

This knowledge could help researchers design new diagnostics, evaluate the healing powers of convalescent plasma, develop new therapeutic treatments, and -- importantly -- help design future vaccines or monoclonal antibody therapies capable of protecting against mutations that may occur in the COVID-19 virus. The findings could help explain the widely varying reactions COVID-19 patients have to the disease.

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