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This Dana-Farber Cancer Institute-led study underscores a need for research into the biological mechanisms underlying the association between being breastfed and colorectal cancer risk, including the role of the microbiome or other pathways as well as the formulation of potential risk-reducing interventions.
Research from Dana-Farber Cancer Institute looks at what happens before the emergence of mutations that interrupt cellular differentiation in colorectal cancer and finds not only evidence of fetal reprogramming that can initiate cancer, but also a protein, Sox9, that fuels that reprogramming.