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Novel therapeutic approach identified for overcoming resistance in B-cell leukemia

Despite having an overall survival rate of 94%, B-cell acute lymphoblastic leukemia (B-ALL), the most common childhood cancer, can prove challenging to treat, with survival among relapsed or resistant cases falling between 30-50%.

Texas , United-states , Xin-huang , Zhejiang , China , Peking , Beijing , Xu-yang , Shaanxi , Charles-mullighan , Seth-karol , Steven-kornblau

Novel Drug Combo Targets B-cell Vulnerability to Treat Leukemia

Novel Drug Combo Targets B-cell Vulnerability to Treat Leukemia
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

Xu-yang , Shaanxi , China , Texas , United-states , Peking , Beijing , Xin-huang , Zhejiang , Jingliao-zhang , William-evans , Elias-jabbour

Targeting vulnerability in B-cell development leads to novel drug combination for leukemia

Targeting vulnerability in B-cell development leads to novel drug combination for leukemia
newswise.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from newswise.com Daily Mail and Mail on Sunday newspapers.

Xu-yang , Shaanxi , China , Peking , Beijing , Xin-huang , Zhejiang , Texas , United-states , Mark-litzow , Huanbin-zhao , Satoshi-yoshimura

Targeting vulnerability in B-cell development leads to novel drug combination for leukemia

Targeting vulnerability in B-cell development leads to novel drug combination for leukemia
newswise.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from newswise.com Daily Mail and Mail on Sunday newspapers.

Xu-yang , Shaanxi , China , Texas , United-states , Xin-huang , Zhejiang , Peking , Beijing , Seth-karol , William-evans , Wenjian-yang

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Scientists atSt. JudeChildren’s Research Hospital are working with colleagues in China to develop better therapy for childhood acute lymphoblastic leukemia (ALL). Results from a large phase 3 noninferiority clinical trial definitively showed that vincristine and dexamethasone pulses can be eliminated in patients with low-risk disease. The findings were published today in
The
Lancet Oncology.
Adding the chemotherapy vincristine plus a steroid (originally prednisone, and later dexamethasone) as pulse therapy for childhood ALL has been part of standard care since the 1970s. This is despite their being associated with neuropsychological side effects, neuropathy and other late effects. However, to date studies about the need for prolonged treatment with pulse therapy have been inconclusive.

Tongji , Sichuan , China , Huazhong , Hubei , Shanghai , Hong-kong , Nanjing , Jiangsu , Hua-jiang , Guangxi , Guangzhou

International collaboration helps refine treatment for childhood leukemia

International collaboration helps refine treatment for childhood leukemia
prnewswire.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from prnewswire.com Daily Mail and Mail on Sunday newspapers.

Tongji , Sichuan , China , Huazhong , Hubei , Shanghai , Hong-kong , Nanjing , Jiangsu , Hua-jiang , Guangxi , Guangzhou