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March 17, 2021 Breast cancer poses a substantial threat as it spreads to other organs, often lying in wait for years in these tissues and recurring without warning. Bones are a prime target, but the mechanisms that influence whether skeletal metastasis will develop or not remain poorly understood. A collaboration between researchers at Cornell and the Max Planck Institute (MPI) of Colloids and Interfaces in Potsdam, Germany, used an innovative combination of biological and materials characterization tools to reveal that bones may actually grow in response to signals from a distant breast tumor – possibly as a preemptive defense mechanism against metastasis. The findings could point the way to future diagnostic tests and therapeutic treatments.

Lara estroffStanley bryerPeter fratzlAarone chiouClaudia fischbachChuang liuCornell centerHuman frontier science programStanford universityMax planck instituteSecreted factors perturb murine bone growthRegions proneBiomedical engineeringNational cancer instituteNational institutesலாரா எஸ்ட்ராஃப்