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Striking increase in SARS-CoV-2 antibodies seen with prime dose AstraZeneca vaccine followed by Pfizer-BioNTech Researchers in Germany have provided evidence that a booster shot of a messenger RNA (mRNA)-based coronavirus disease 2019 (COVID-19) vaccine following prime immunization with AstraZeneca’s adenoviral vector-based vaccine is sufficient to achieve high levels of neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The team – from the University Hospital Erlangen, the University Hospital of Cologne, and the Technical University of Munich – says that this heterologous prime-boost regimen using different COVID-19 vaccines may even increase the efficacy of vaccination, while providing an alternative approach to immunization in settings where vaccines are in short supply.

Ulrike protzerSally robertsonMann whitneyTechnical university of munichPanelc dotPanelb dotUniversity hospital of cologneUniversity hospital erlangenUniversity hospitalTechnical universityசாலி ராபர்ட்சன்மான் விட்னிதொழில்நுட்ப பல்கலைக்கழகம் ஆஃப் முனிச்பல்கலைக்கழகம் மருத்துவமனை ஆஃப் கொலோன்பல்கலைக்கழகம் மருத்துவமனைதொழில்நுட்ப பல்கலைக்கழகம்