Alzheimers breakthrough a us company says its ready to market a new drug that can slow down the disease. Hello. In the latest twist in the saga of britain trying to leave the european union, Prime Minister borisjohnson has suffered another major defeat in parliament. Mps voted to reject his fast track timetable to pass the eu Withdrawal Agreement through the house of commons. He did actually win another vote to advance the legislation, itself a significant victory. But the timetable defeat means hes been forced to pause the whole process, which means a new extension may be needed from european leaders. This from our Political Editor laura kuenssberg. A rare moment of silence. And then a result. The ayes to the right 308, the noes to the left 322. Mps kicked out the Prime Ministers timetable for speeding his brexit deal through parliament. Plenty of mps dont want to leave, but even for those who do, a majority in here tonight thought it was happening too fast. Tonight the house has refused to be bounced into debating a hugely significant piece of legislation in just two days with barely any notice and an analysis of the Economic Impact of this bill. The Prime Minister is the author of his own misfortune. So i make this offer to him tonight, work with us, work with us, all of us, to agree a reasonable timetable and i suspect this house will vote to debate, scrutinise and i hope amend the detail of this bill. I must express my disappointment that the house has again voted for delay. Rather than a timetable that would have guaranteed that the uk would be in a position to leave the eu on october 315t with a deal. And we now face further uncertainty and the eu must now make up their minds over how to answer parliaments request for a delay. The opposition parties all said no to the Prime Ministers pace. This is yet another humiliating defeat for the Prime Minister this evening. Who has sought to railroad through this house, legislation that requires proper scrutiny. The house has made a very wise decision to allow further time for detailed examination of some of the most important legislation that we will ever have to consider. There is now more opportunity to release the Economic Impact assessments which we should all have sight of before we make such material decisions. But minutes before, mps did give their permission for the Prime Ministers deal to move to the next stage. Miles from agreeing it overall, but a milestone nonetheless. Parliament has approved tonight for the first time a version of brexit. The ayes to the right, 329. The noes to the left, 299. How welcome it is, evenjoyful, that for the first time in this long saga, this house has actually accepted its responsibilities, together, come together and embraced a deal. We should not overlook the significance of this moment. Hear, hear and i pay particular tribute to those members of the house who were sceptical and who had difficulties and doubts and who decided to place the National Interest ahead of any other consideration. But what on earth happens next . One way or another, we will leave the eu with this deal to which this house has just given its assent. We were meant to be leaving the eu in nine days time but tonight instead mps are at odds with each other and scratching their heads. This is a bad deal, its a hard brexit, its not what people voted for. It bears no resemblance to the promises that were made in 2016, so at the very least it should go back to the public. The house of commons is entitled to amend it. This is where the Prime Minister seems to me to be behaving so badly, and now hes i dont know what hes doing. Really what we want is a general election because what is clear is the conservative party is in government but with a 44 majority, we are not in power. The chief negotiator didnt want to be drawn tonight. Do you think there will be an extension . But they cant and wont just shrug it off. President of the eu council, donald tusk, has already written online tonight he will recommend the delay the Prime Minister has had to ask for. Many mps who sit down there hope it wont be the case, but delay could soon mean the decision for all of us at the ballot box, an election. Laura kuenssberg, bbc news, westminster. In washington dc, the top american diplomat in ukraine has given a congressional investigation a highly damaging account of President Trumps dealings with the ukrainian leader now of course the subject of an impeachment inquiry. Acting Ambassador William Taylor said he was told that mr trump had made the release of military aid to ukraine contingent on a public declaration from kiev that it would investigate one of mr trumps rivals for the presidency, former democratic Vice President , joe biden. Mr taylor said he found the demand politically troubling. Mr trump has denied he did anything wrong. For more on this, lets talk to our north america correspondent david willis. This was evidence behind closed doors, but it has been leaked . M has. William taylor is of course a career diplomat, he is somebody who has served both republican and democrat administrations since 1985. He came out of retirement to become americas top diplomat in the ukraine. Hejustified americas top diplomat in the ukraine. He justified for more than nine hours on capitol hill today, and very damning evidence saying that very shortly after arriving in kiev to take up that position he became aware there were two channels, if you like, of us policy making. The official channel of which he was a part, and the other, an unofficial channel made up of disparate characters such as the personal lawyer to President Trump, rudy giuliani, and others he said the official channel was involved in basically Security Issues and corruption issues and so on in ukraine, the unofficial channel was devoted, it seemed, he said, to linking 400 million in aid money, foreign aid money to ukraine, to political favours. And foreign aid money to ukraine, to politicalfavours. And in this particular case, some sort of enquiry into the behaviour ofjoe biden, is political rival and his son who was in the ukraine at the time. Mr taylor said such a policy was crazy, and he pointed that out more than once, mike. He seems to be saying the aid was dependent not only on an investigation being set up only on an investigation being set up at the ukrainian leader going to a microphone and making a very public declaration of it. A tricky one for the jump white house because this is a hard witness to discredit, isnt it . Very hard. And in actual fa ct, isnt it . Very hard. And in actual fact, the white house has put out a statement in the last hour or so saying that President Trump did nothing wrong, there was no quid pro quo, and this impeachment enquiry represented in the words of the statement a co ordinated Smear Campaign from phar lap lawmakers and radical, unelected bureaucrats, waging waron radical, unelected bureaucrats, waging war on the constitution. But this claim from William Taylor is a very significant one, not least because the clout he has, he has no dog in the fight, if you like, he has retired now. And also the fact that there will be other people coming to give evidence in the next few days behind closed doors who are likely to corroborate his version of events, michael. David, thank you very much. Lets get some of the days other news. A second night of violent protests in bolivia over the hotly disputed election result. According to the foreign minister, president evo morales wants transparency and the organization of american states to audit the vote count. 0pposition supporters have also cried foul over the lengthy delay in counting. Police and protesters have clashed for a fifth day in a row in the chilean capital, santiago, as demonstrations continue against social inequality and price hikes. The president pinera, says he has requested meetings with opposition leaders in an attempt to come to a solution. The protests erupted last friday, with a state of emergency declared in ten cities. Lawyers for shamima begum, the british teenager who went to syria to join the extremist group, the so called islamic state, say the decision to strip her of uk citizenship has left her at risk of being hanged. Her lawyers say shes now effectively stateless and had professed sympathy for the group, in media interviews, only to try to protect herself and her son. The American Woman whos a suspect in the fatal crash that killed a young british motorcyclist has asked to be interviewed in the united states, by british police. Anne sacoolas left the uk after the crash, claiming immunity from prosecution. Russia and turkey have agreed a deal to extend the current shaky ceasefire in north east syria for at least another six days. They say the aim is to give kurdish fighters time to withdraw 30 kilometres from the border. Meeting in the russian city of sochi, president erdogan and president putin agreed that joint russian and turkish patrols will operate inside syria, within 10 kilometres of the border. 0ur correspondent, jiyar gol, reports from the syrian town of qamishli, close to the border, on the human toll on the current fighting. As we crossed the tigris river from iran into syria, its not long before we bump into dozens of military vehicles heading the opposite way. This is an american convoy. You can see american flags. They are pulling out of the region. It seems to me they are special forces. They have been here in the past three years aiding the kurds in the fight against isis. 11,000 kurdish men and women were killed in the war against the islamic state. Now their long term ally, the us, is leaving them to face an even bigger threat alone. In a hospital in the town of qamishli, a few kilometres away from the turkish border, we met kurdish fighters hit by turkish bombs. 21 year old bafrin is a member of a kurdish all female unit who fought is in manbij and raqqa. Turkey says clearing a safe zone is vital to protect its borders from kurdish militancy. But its not only the fighters being hit. Tens of thousands of civilians have been forced to leave their homes, and at least 120 people have lost their lives. One of them was saras brother. Her parents havent told her the news. Shes got too much to cope with. She cries. With us troops leaving, syrian kurds like sara face an uncertain future. Jiyar gol, bbc news, qamishli, in Northern Syria. An American Pharmaceutical Company says it may have developed the first drug to slow alzheimers disease. Biogen says it will soon ask us regulators for approval. Current drugs only help with the symptoms of alzheimers so if given the go ahead, it will be a major breakthrough in the treatment of the disease. Heres our medical correspondent fergus walsh. This is an extraordinary turnaround for this drug which is called aducanumab. Back in march, biogen suddenly without warning, halted Clinical Trials involving more than 3,000 patients worldwide, some of them in the uk, saying this drug does not work. Well, now its analysed more data and its said for patients with early alzheimers, on the higher doses, it does bring significant clinical benefits, slowing their cognitive decline and allowing them to preserve more of their memory, Language Skills and ability to do things like wash and dress themselves. Weve got to be cautious because scientists havent seen all of the data yet. But if it does work, it would be the first drug to slow alzheimers and it would be a massive medical breakthrough. It would be a blockbuster drug, and it would be transformative for this field of research. Fergus walsh for us. Stay with us on bbc news. Still to come moving day the 700 ton lighthouse that was getting a little too close to the sea. A historic moment that many of his victims have waited for, for decades. The former dictator in the dock, older, slimmer, and, as he sat down, obedient enough. Dawn, and as the sun breaks through the piercing chill of night on the plain outside korem, it lights up a biblicalfamine, now, in the 20th century. The depressing conclusion, in argentina today, its actually cheaper to paper your walls with money. Weve had controversies in the past with great britain. But as good friends, weve always found a good and lasting solution. Concorde bows out in style. After almost three decades in service, an aircraft that enthralled its many admirers for so long taxis home one last time. This is bbc news. The latest headlines the uk is set for another brexit delay after borisjohnson loses a vote to rush his deal through parliament. Americas top diplomat in ukraine gives damaging testimony about Donald Trumps dealings with the countrys president. Justin trudeau has won a second term as Prime Minister of canada but his liberal party lost its majority and the popular vote. Mr trudeau had to answer for a number of scandals that plagued his first term. Now he must set about forming a coalition to support his manifesto commitments. The bbcs chief International Correspondent lyse doucet reports from toronto. The morning after, selfies on the subway. Canadians queueing for a photo with the Prime Minister. Just whatJustin Trudeau did four years ago when he first swept into power. But this time it is different. Rousing cheers and great relief at liberal Party Headquarters in the early hours of the morning. A better result than all the polls predicted. But they lost their majority. And to those who did not vote for us, know that we will work every single day for you. We will govern for everyone. Whether you knocked on doors. A sign of what is to come. This is not how things are normally done. Normally we wait our turn so we are off to a great start for this minority government. Leaders already talking over each other. Minority governments do not tend to last longer than two years. A clear warning from his conservative rival. Canadians have passed judgement onJustin Trudeau and on his four years of scandals and mismanagement. And as we gained, Justin Trudeau and the liberals lost. If you look at the map you will see there is a lot of colours from one coast to the other. The map of canada spells it out in full colour. Liberal support scattered from coast to coast. And in the west, a deep blue conservative sweep across the oil rich provinces. Canada is a difficult country to govern because of regions and what is good for one region may not be good for another. And that may be because of climate policy, because of housing but it is difficult and it will be even more difficult in a minority government. The democrats have been given a critical role. 0n the left, these new democrats lost seats but they say they will work with trudeau on issues that matter to them. Whatever the differences here, the Political Centre in canada still holds. A far right populist party surfaced in these elections but was soundly defeated. Canada prides itself on diversity and tolerance and both will be tested again and again in the days ahead. The man whose extradition case spa weeks of protests in hong kong has agreed to return to taiwan. He is accused of assaulting his girlfriend in taiwan but fled to hong kong which does not have extradition rules. That sparked the ryer after the development of an extradition bill. Breast Cancer affects more than two million women each year at least a quarter lose their lives, according to the world health 0rganization. But in pakistan, fighting Breast Cancer also means challenging taboos. Early detection is essential, but cultural pressures to be modest mean many women are not coming forward. Shabnam mahmood reports. In our society, especially women, they try to hide things. And when i felt there was a lump, i couldnt tell my brothers or my father, or my sisters. When silva discovered a lump in her breasts, she told no one for almost six months because of the stigma around the word breasts in pakistan. Probably it was midnight, this piercing pain, it made me wake up and i was like, ouch. And that was the time i was like, ijust cannot hide it any more. By the time silva got help, her cancer had reached an advanced stage. Here in pakistan, every year, Breast Cancer claims the lives of about 40,000 women. Thats like five deaths every hour of every day. Doctors say Early Detection is key, but due to social taboos around the subject, many women are reluctant to get tested. Some like 20 year old sobia worry about the impact on their future. Translation this is a very private part of our body which we cannot discuss in front of people. Young unmarried girls wont get any Marriage Proposal if they have the disease. That is not a good thing and that is why you have to hide it. Womens health is often a low on the agenda here. According to one leading breast surgeon, women of poor backgrounds living in rural areas are particularly affected. The services are all concentrated in bigger cities. So if somebody has an issue, the whole family needs mobilisation, they need to travel, there is a social Economic Cost to the earning members. Men of the family who decide if you are going to be checked and where are you going to be checked. So men also need to be educated. Cancer charities are already trying to change attitudes. This month, the Pink Ribbon Foundation is lighting up key buildings in pakistan to raise awareness of Breast Cancer. It is also touring schools and colleges to educate young girls about the importance of self examination. The message is that if you know that you are facing this, you cannot hide. You cannot waste time. Every minute counts. Every minute. Silva is now in remission, she hopes by sharing her story, she can help other women seek help before it is too late. In denmark a 120 year Old Lighthouse has been moved to save it from falling into the sea. It weighs around 700 tons, so shifting it was quite the operation as the bbcs tim allman explains. For more than a century it has stood on these shores protecting sailors and ships alike. But coastal erosion had finally caught up with the Rubjerg Knude lighthouse. It would have to be abandoned, demolished or moved. And in the end, they chose option number three. Translation it is a big day for us. We have been on the sidelines from the beginning when we did not even know if it was possible to move the lighthouse. But it was possible. The entire structure lifted by hydraulics and slowly carried at a dizzying speed of eight metres an hour. It was pushed along two tracks, a process described as being Something Like skating on rails. Thousands of spectators looking on as the lighthouse was moved some 70 metres, more than 200 feet. Translation i felt very confident that, of course, i am relieved that it is done. Especially as it is so important for northern jutland but also for all of denmark. Concrete was poured in at the destination to provide support. This whole operation is expected to safeguard the lighthouse for another 40 years when, presumably, everyone will come back and do it all over again. Just time for these pictures from the arctic. These are some of the five new islands which have appeared from underneath melting glaciers there. They were found by the russian navy as russia and other nations are hoping to open up new shipping routes and exploit resources that have become easier to reach now that Global Warming is shrinking arctic ice. Although the russians clearly werent really the first to find them, these islands have been home to many species of wildlife like these walruses for years. And you can get in touch with me and most of the team on twitter im bbcmikeembley. And the heads up on something we will bring you in an hour or so. The hong kong legislative council, is expected to formally withdraw the controversial extradition bill, one of the five demands from the protesters. It is a formal withdrawal. But it may be too late to alter the trajectory of the conflict to a police and protesters which has an a momentum of its own. Dont forget, more on the news at any time on the bbc website. Hello there. Tuesday was a dry day up and down the country with plenty of sunshine around and a bit warmer early in the south, thanks to a ridge of High Pressure that will be with us on wednesday morning that we have a weather system to the north west of the country and a weather front across the south east. Rain and strong wind across the north west to begin wednesday, perhaps a couple of showers in the south east elsewhere a dry start to the day with mist and fog around. A chilly start temperatures will rise as we head through the morning as we see sunshine around. Best of sunshine into the afternoon across the midlands and south west with more cloud and you showers in the south east, increasingly wet and windy across the north and west and that applies for Northern Ireland. Temperatures 13 15. As we had through wednesday evening and night the weather front peps up across the south east, this one across the south east, this one across the south east, this one across the west tends to move south east into a merge together. A cloudy and to the night across england and wales and a milder night with clear skies and showers across north west. Into thursday, low pressure firm in control across the north of the country bringing a speu north of the country bringing a spell of showery and windy weather to scotland and Northern Ireland through the day. Some showers could turn out to be heavy and thundery into the afternoon and the wind picking up with gusts of 50 60 mile an hourfor the picking up with gusts of 50 60 mile an hour for the north picking up with gusts of 50 60 mile an hourfor the north and picking up with gusts of 50 60 mile an hour for the north and west of scotla nd an hour for the north and west of scotland to eastern england, the weather front bringing outbreaks of rain slowly pushing eastwards leading leaving sunshine in the west and the temperature is 12 15 degrees. As we head on into friday, signs of cold air invading across the north of the country. Mild in the north of the country. Mild in the south but the cold air will wind out as we had through the weekend. What we will see on fridays this feature running up off the atlantic in the south west. Low pressure and an active weather front bringing outbreaks of rain. It will start windy across the north of scotland with low pressure nearby and further showers to get dry start elsewhere, cloudy and wetter with heavy rain across northern and Western Areas and is that rain bumps into the cold air across scotland and Northern Ireland we can see sleet and snow over the high ground. Another mild day across the south east. As we head on into the weekend, it is wet for saturday so the combination of the rain on friday and saturday could cause some travel issues. Stay tuned to the weather. This is bbc news. The headlines british members of parliament have backed borisjohnsons brexit deal but rejected a plan to give them just three days to scrutinise its detail. The timetable defeat means hes been forced to pause the whole process, which means a new extension may be needed, from european leaders. It leaves the Withdrawal Agreement bill in limbo. The top american diplomat in ukraine has given the congressional impeachment investigation a highly damaging account of President Trumps dealings with the ukrainian leader. Acting Ambassador William Taylor said he was told that mr trump had made the release of military aid to ukraine contingent on a public declaration from kiev that it would investigate joe biden, one of mr trumps rivals for the presidency. Turkey and russia have agreed to joint patrols in parts of Northern Syria to ensure that Kurdish Forces do not return to areas close to syrias border. These will begin on wednesday there will be joint russian and syrian patrols where Turkish Forces dont operate. Its about 3 30am. Stay with us. Much more to come. 0n panorama tonight scandal in the city. I think this has just undermined the whole trust in the whole system. We investigate the man who gambled billions and lost. At the very least, he should be drummed out of financial services. He has no right to be managing other peoples money. The industry knew Neil Woodford was in trouble, but no one told investors. What do you think about the way youve been protected . Well, i havent been protected at all, have i . We also reveal how another money man was doing secret deals on the side