Deeper proteome coverage and faster throughput for low input samples on the Thermo Scientific Orbitrap Astral mass spectrometer

In recent years there has been a shift to analyzing smaller sample quantities, driven by the interest in profiling the proteome of individual cells. This increased focus on LC-MS analysis of limited sample amounts (e.g., single-cells) requires the highest possible sensitivity. At the same time, throughput and chromatographic performance must be preserved to generate sufficiently high-quality data from large data sets to draw meaningful conclusions. Traditional proteomics approaches read out the

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