Dynamic Vapor Sorption for the Determination of Moisture-Induced Glass Transition in an Amorphous Pharmaceutical

A new method to determine the onset relative humidity for a glass transition in an amorphous material was developed using the DVS. Water vapour can act as a plasticising agent in amorphous materials, causing a recrystallisation event below the glass transition temperature. This method calculates the threshold relative humidity for this moisture induced glass transition at a particular temperature.

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