About 300 people were expected to start flying out of the community Thursday and were to be put up in hotels in Winnipeg and Brandon, Man.
The Red Cross said it hoped to have those evacuees out by the end of the night, but added evacuations could continue into the weekend.
It's the fifth Manitoba First Nation whose members have been forced to leave their homes this week.
Most people from the Little Grand Rapids, Bloodvein and Berens River First Nations have left, while Pauingassi First Nation completed its evacuation on Monday.
There are about 2,000 people displaced and the number is growing.