When Gavi’s board meets in Accra, Ghana, next week, advancing discussions on a new five-year strategic period, known as “Gavi 6.0,” will be a top agenda item. But conversations about Gavi’s future direction are also taking place against the backdrop of a leadership transition and a rapidly changing global landscape that is surfacing challenges for its existing model. As part of an ongoing CGD project on Gavi’s future, together with our colleagues, we’ve compiled a series of analyses and recommendations for Gavi’s board to consider in its upcoming strategy discussions.